Three girls have been chosen by the great Shinju-sama to be heroes and fight against the destructive beings known as Vertexes—enemies that threaten the harmony and safety of the world. Unsure of when they would be called to duty, Sumi Washio, Sonoko Nogi, and Gin Minowa spent their time idly. However, with the sudden appearance of a Vertex, they realize they have no idea how to fight together as magical girls when they are nearly bested. They manage to defeat their enemy by sheer determination, but in the aftermath of the battle, the three decide to fix their teamwork issues and improve their combat capabilities. But as more enemies appear—and requiring even more power to defeat their nemeses—the girls may find themselves irreversibly changed by the use of their magic. What price will they have to pay to ensure victory, and is it one worth paying if humanity will be saved?

An arrogant scientist awakens in the middle of a muddy pigpen, and the last thing he remembers is eating a raw pig liver and collapsing in the subway. He quickly gathers that he has turned into a pig and is now in a strange fantasy land. As he struggles to grasp reality, a young girl named Jess comes to his aid. Jess happens to be a Yesma—a discriminated class of servants distinguished by their telepathic abilities and the silver collars around their necks. Despite his inappropriate thoughts about her, Jess makes sacrifices for his sake, and the pig resolves to repay her the best he can within the limits of his new body. But Jess' generosity does not absolve her from the prejudice the Yesmas face daily, and the pig begins to suspect that Jess is in greater danger than she thinks. While he wants to visit the royal capital and beg the king to change him back into a human, the pig realizes that he cannot simply turn his back on his kind savior.

Rebel organization Reunion has reduced the city of Chernobog to ashes and despair. That is only the beginning of its uprising against the nations prejudiced toward those infected with the highly contagious and deadly disease Oripathy. Now, the rebels have set their sights on Lungmen—a prosperous city infamous for its inhumane treatment of the sick. After witnessing Reunion destroy her homeland, Chief Ch'en of the Lungmen Guard Department's Special Inspection Unit leads her squad to defend her city. Meanwhile, Amiya, the Doctor, and the rest of the advanced pharmaceutical company Rhodes Island continue to oppose Reunion on all fronts. However, they soon find themselves in a deadlock against a powerful enemy: FrostNova, a Reunion commander whose fearsome wintry powers cause anyone unfortunate enough to stand in her way to slowly perish in frost.

Since childhood, 15-year-old Umika Konohoshi has been fascinated by aliens, hoping to one day voyage to outer space and befriend them. Unfortunately, this fixation has caused her peers to label her as odd, intensifying her struggle with severe social anxiety. Nevertheless, Umika's passion for the extraterrestrial persists, and she deeply believes that her true purpose is outside the confines of Earth. On her first day of high school, Umika's wish of meeting an alien seems to have finally come true when she encounters Yuu Akeuchi—a classmate who claims to have crash-landed on Earth with no recollections of her past. Umika tries to seize this opportunity to make friends with Yuu, but her lack of confidence hinders her. Sensing Umika's distress, Yuu suddenly uses a strange power to delve deep into her mind, thus sparking a friendship that may just help Umika reach her dreams.