Some offices have stereotypical dynamics: the chauvinistic pig of a boss who never does any real work; the employees whose goal is to suck up to the boss; the ones whose lives seem perfect; and the individuals who have all the actual work pushed onto them. Retsuko the red panda is in the last group, as she stays late most nights to make up the work her coworkers are too lazy to do themselves. Her relief from the stress of her everyday life comes in the form of singing death metal at a local karaoke club. Night after night, Retsuko channels her grief into a microphone and considers the place to be her own personal sanctuary. But as she moves further away from her comfort zone and the ideas people have of her, she discovers that letting others into her world of death metal may not be such a bad thing.

After participating in the Johto League, Satoshi decides to begin anew in yet another journey; this time by himself and Pikachu, in the land of Houen. Though he isn't alone for long, as 10-year-old Haruka (whom dislikes Pokemon, but just wants to come along to see the world) travels with him after Pikachu destroys her bicycle. Satoshi also meets up with his old companion, Takeshi, and Haruka's younger brother, Masato. Together, they travel along in Houen, battling Gym Leaders, entering contests, and other events on the way to the Houen League. (Source: ANN, edited)

Ken Usato, an ordinary high schooler, wishes for something fantastical to occur in his unremarkable life. Such an opportunity arrives when he is transported to another world alongside Kazuki Ryuusen and Suzune Inukami, two prodigious members of his school's student council. Arriving in Llinger Kingdom, the three are deemed to be the heroes tasked with stopping the impending invasion by the Demon Lord's army. However, this is a misunderstanding—Usato was summoned by accident and, unlike his two friends, is not one of the heroes. Despite this disheartening revelation, Usato learns that he has an aptitude for the extremely rare healing magic. This catches the attention of Rose, the intimidating captain of the kingdom's Rescue Team, who forcibly takes custody of Usato to mold him into a full-fledged healer. As he undergoes grueling training under Rose's supervision, Usato resolves to become capable enough to protect his friends from the dangers of this world.

During the 21st century, humanity attempted to colonize Mars by sending two species which could endure the harsh environment of the planet to terraform it—algae and cockroaches. However, they did not anticipate the species' remarkable ability to adapt. Now in the 26th century, a lethal disease known as the Alien Engine Virus has arrived on Earth, and the cure is suspected to be found only on Mars. The problem is, Mars in the present is overrun by creatures known as Terraformars, incredibly powerful and intelligent humanoid cockroaches that mutated from those originally sent to the planet. The Annex I team, consisting of a hundred men and women genetically enhanced with characteristics of powerful organisms from earth, has been sent to Mars on a mission to find the cause of the Alien Engine Virus and to help cure humanity—signalling the start of the crew's fight for survival.