Due to a sudden accident, twins Haruka and Sora Kasugano have lost both of their parents. Starting their lives anew, they return to their childhood home—living once again in the rural, quaint town like they did four years ago. However, revisiting such a nostalgic place also means recalling all the memories the two of them made together, be it those that gave them blissful joy or those that made them suffer painful sorrow. Meeting both old acquaintances and new companions alike, the story of Haruka and Sora only gets more convoluted as their lives are slowly influenced by different acts of love, friendship, envy—and perhaps even lust.

The rigorous city life of China, while bustling and unforgiving, contains the everlasting memories of days past. Three stories told in three different cities, Shikioriori follows the loss of youth and the daunting realization of adulthood. Though reality may seem ever changing, unchangeable are the short-lived moments of one's childhood days. A plentiful bowl of noodles, the beauty of family and the trials of first love endure the inevitable flow of time, as three different characters explore the strength of bonds and the warmth of cherished memories. Within the disorder of the present world, witness these quaint stories recognize the comfort of the past, and attempt to revive the neglected flavors of youth.

The Medicine Seller is a deadly and mysterious master of the occult who travels across feudal Japan in search of malevolent spirits called mononoke to slay. When he locates one of these spirits, he cannot simply kill it; he must first learn its Form, its Truth, and its Reason in order to wield the mighty Exorcism Sword and fight against it. He must begin his strange exorcisms with intense psychological analysis and careful investigative work—an extremely dangerous step, as he must first confront and learn about the mononoke before he even has the means to defeat it. The Medicine Seller's journey leads him to an old-fashioned inn where Shino, a pregnant woman, has finally found a place to rest. The owner has reluctantly placed her in the last vacant room; however, as she settles in, it quickly becomes clear that the room is infested by a lethal band of mononoke, the Zashiki Warashi. With his hunter's intuition, the Medicine Seller begins his investigation to discover the Form, the Truth, and the Reason before the Zashiki Warashi can kill again.

In the light of day and in the dead of night, mysterious horrors await in the darkest shadows of every corner. They are unexplainable, inescapable, and undefeatable. Be prepared, or you may become their next victim. Sit back in terror as traumatizing tales of unparalleled terror unfold. Tales, such as that of a cursed jade carving that opens holes all over its victims' bodies; deep nightmares that span decades; an attractive spirit at a misty crossroad that grants cursed advice; and a slug that grows inside a girl's mouth. Tread carefully, for the horrifying supernatural tales of the Itou Junji: Collection are not for the faint of heart.