Idly indulging in baseless paranormal activities with the Occult Club, high schooler Yuuji Itadori spends his days at either the clubroom or the hospital, where he visits his bedridden grandfather. However, this leisurely lifestyle soon takes a turn for the strange when he unknowingly encounters a cursed item. Triggering a chain of supernatural occurrences, Yuuji finds himself suddenly thrust into the world of Curses—dreadful beings formed from human malice and negativity—after swallowing the said item, revealed to be a finger belonging to the demon Sukuna Ryoumen, the King of Curses. Yuuji experiences first-hand the threat these Curses pose to society as he discovers his own newfound powers. Introduced to the Tokyo Prefectural Jujutsu High School, he begins to walk down a path from which he cannot return—the path of a Jujutsu sorcerer.

Death is one of many mysteries that has left humanity in the dark since the dawn of time. However, the burning question of what happens to the soul after one dies is soon answered to 17-year-old Yuzuru Otonashi. Waking up with no previous memories in a dimension between life and death, he discovers the unsettling truth of the afterlife. Taking the form of a high school, this bizarre dimension is designated to shelter those who died unwanted deaths. Feeling wronged by God during their earthly lives, the school's residents have decided to form the Afterlife Battlefront—a rebellious faction determined to oppose their god-like student council president, Kanade Angel Tachibana. The group's leader, Yuri Nakamura, recruits Otonashi in their fight against Angel in order to take control of their own lives. However, questioning the morality behind their actions, Otonashi takes a step behind the enemy lines to understand the opposing side of their common fate.

Tucked in the mountains near the elite Kunugigaoka Middle School lies a small derelict building that houses the delinquents and dropouts of Class 3-E. Looked down upon by their peers, the students in this class appear to have little hope in advancing their academic careers. That is, until the national government tasks them with eliminating the greatest threat to their planet: their new teacher. Having already destroyed the moon, the octopus-like professor—dubbed Koro-sensei—has now threatened to destroy the Earth by March of the following year. In light of their mission, the students have found that killing him is easier said than done. Not only can Koro-sensei move at speeds of up to Mach 20, but he can also resist almost every earthly weapon. Ironically, he also proves to be one of the best teachers Class 3-E has ever had. Training the class to excel in both their studies as students and skills as assassins, Koro-sensei is confident that his students' ingenuity and indomitable will could return them to the main campus. Through trial and error, Nagisa Shiota, as well as the other students of Class 3-E, must figure out Koro-sensei's weaknesses—and fast, for the very fate of the world depends upon it.

If not for his ability to take over people's mind and body, Yuu Otosaka would be an ordinary high school student. Though it only lasts for five seconds at a time, Yuu's mysterious power allowed him to cheat his way to the top of his class and enter a prestigious high school, where he continues his dishonest acts. His shenanigans are eventually stopped by Nao Tomori—the headstrong student council president from Hoshinoumi Academy—who sees through his deceit. Through coercion, Nao convinces Yuu to transfer to Hoshinoumi and join the student council. Hoshinoumi Academy is secretly an institution created for adolescents who possess supernatural abilities—with the student council serving as a means of locating those who abuse their powers. With Yuu begrudgingly assisting in council affairs, the group sets out to find and protect new ability users from harm. However, as they further investigate the abilities, their findings entangle them in far more complicated matters than they could ever imagine.