After a horrific alchemy experiment goes wrong in the Elric household, brothers Edward and Alphonse are left in a catastrophic new reality. Ignoring the alchemical principle banning human transmutation, the boys attempted to bring their recently deceased mother back to life. Instead, they suffered brutal personal loss: Alphonse's body disintegrated while Edward lost a leg and then sacrificed an arm to keep Alphonse's soul in the physical realm by binding it to a hulking suit of armor. The brothers are rescued by their neighbor Pinako Rockbell and her granddaughter Winry. Known as a bio-mechanical engineering prodigy, Winry creates prosthetic limbs for Edward by utilizing automail, a tough, versatile metal used in robots and combat armor. After years of training, the Elric brothers set off on a quest to restore their bodies by locating the Philosopher's Stone—a powerful gem that allows an alchemist to defy the traditional laws of Equivalent Exchange. As Edward becomes an infamous alchemist and gains the nickname Fullmetal, the boys' journey embroils them in a growing conspiracy that threatens the fate of the world.

Ever since the death of his father, the burden of supporting the family has fallen upon Tanjirou Kamado's shoulders. Though living impoverished on a remote mountain, the Kamado family are able to enjoy a relatively peaceful and happy life. One day, Tanjirou decides to go down to the local village to make a little money selling charcoal. On his way back, night falls, forcing Tanjirou to take shelter in the house of a strange man, who warns him of the existence of flesh-eating demons that lurk in the woods at night. When he finally arrives back home the next day, he is met with a horrifying sight—his whole family has been slaughtered. Worse still, the sole survivor is his sister Nezuko, who has been turned into a bloodthirsty demon. Consumed by rage and hatred, Tanjirou swears to avenge his family and stay by his only remaining sibling. Alongside the mysterious group calling themselves the Demon Slayer Corps, Tanjirou will do whatever it takes to slay the demons and protect the remnants of his beloved sister's humanity.

Hunters devote themselves to accomplishing hazardous tasks, all from traversing the world's uncharted territories to locating rare items and monsters. Before becoming a Hunter, one must pass the Hunter Examination—a high-risk selection process in which most applicants end up handicapped or worse, deceased. Ambitious participants who challenge the notorious exam carry their own reason. What drives 12-year-old Gon Freecss is finding Ging, his father and a Hunter himself. Believing that he will meet his father by becoming a Hunter, Gon takes the first step to walk the same path. During the Hunter Examination, Gon befriends the medical student Leorio Paladiknight, the vindictive Kurapika, and ex-assassin Killua Zoldyck. While their motives vastly differ from each other, they band together for a common goal and begin to venture into a perilous world.

A sinister threat is invading Tokyo: flesh-eating ghouls who appear identical to humans and blend into their population. Reserved college student Ken Kaneki buries his nose in books and avoids the news of the growing crisis. However, the appearance of an attractive woman named Rize Kamishiro shatters his solitude when she forwardly asks him on a date. While walking Rize home, Kaneki discovers she isn't as kind as she first appeared, and she has led him on with sinister intent. After a tragic struggle, he later awakens in a hospital to learn his life was saved by transplanting the now deceased Rize's organs into his own body. Kaneki's body begins to change in horrifying ways, and he transforms into a human-ghoul hybrid. As he embarks on his new dreadful journey, Kaneki clings to his humanity in the evolving bloody conflict between society's new monsters and the government agents who hunt them.