In the coastal city of Naples, corruption is teeming—the police blatantly conspire with outlaws, drugs run rampant around the youth, and the mafia governs the streets with an iron fist. However, various fateful encounters will soon occur. Enter Giorno Giovanna, a 15-year-old boy with an eccentric connection to the Joestar family, who makes a living out of part-time jobs and pickpocketing. Furthermore, he is gifted with the unexplained Stand ability to give and create life—growing plants from the ground and turning inanimate objects into live animals, an ability he has dubbed Gold Experience. Fascinated by the might of local gangsters, Giorno has dreamed of rising up in their ranks and becoming a Gang-Star, a feat made possible by his encounter with Bruno Bucciarati, a member of the Passione gang with his own sense of justice. JoJo no Kimyou na Bouken: Ougon no Kaze follows the endeavors of Giorno after joining Bruno's team while working under Passione, fending off other gangsters and secretly plotting to overthrow their mysterious boss.

On December 24, 2029—the day colloquially known as the Lost Christmas—the Apocalypse Virus spread across Japan, bringing death to its citizens and plunging the country into utter chaos. In an effort to establish order, the United Nations sends the GHQ to assist with the crisis by containing the outbreak while removing all political autonomy in the process. A decade later, the country still lives under their control, unable to break free from their draconian rule. Frustrated with the state of the nation, a resistance group named the Funeral Parlor aims to liberate Japan from the GHQ. Led by the charismatic Gai Tsutsugami, the group plots to steal a vial containing the Void Genome to further their goals. The vial falls into the hands of internet vocalist Inori Yuzuriha, who ends up being hunted by the GHQ's Anti-Bodies forces. Having nowhere to go, she seeks refuge in a warehouse where she meets Shuu Ouma—a socially awkward high school student who is a huge fan of her music. Shuu gets dragged into the conflict the moment he rescues Inori, and the Void Genome shatters in his hand, granting him the Power of the Kings. While learning how to control his grand new ability, Shuu must now fight to liberate Japan from its cruel oppressors.

The greedy samurai lord Daigo Kagemitsu's land is dying, and he would do anything for power, even renounce Buddha and make a pact with demons. His prayers are answered by 12 demons who grant him the power he desires by aiding his prefecture's growth, but at a price. When Kagemitsu's first son is born, the boy has no limbs, no nose, no eyes, no ears, nor even skin—yet still, he lives. This child is disposed of in a river and forgotten. But as luck would have it, he is saved by a medicine man who provides him with prosthetics and weapons, allowing for him to survive and fend for himself. The boy lives and grows, and although he cannot see, hear, or feel anything, he must defeat the demons that took him as sacrifice. With the death of each one, he regains a part of himself that is rightfully his. For many years he wanders alone, until one day an orphan boy, Dororo, befriends him. The unlikely pair of castaways now fight for their survival and humanity in an unforgiving, demon-infested world.

Shinji Ikari is left emotionally comatose after the death of a dear friend. With his son mentally unable to pilot the humanoid robot Evangelion Unit-01, Gendou Ikari's NERV races against the shadow organization SEELE to see who can enact their ultimate plan first. SEELE desires to create a godlike being by fusing their own souls into an Evangelion unit, while Gendou wishes to revert all of humanity into one primordial being so that he can be reunited with Yui, his deceased wife. SEELE unleashes its military forces in a lethal invasion of NERV headquarters. As SEELE's forces cut down NERV's scientists and security personnel, Asuka Langley Souryuu pilots Evangelion Unit-02 in a desperate last stand against SEELE's heaviest weaponry. The battle rages on, and a depressed Shinji hides deep within NERV's headquarters. With the fate of the world resting in Shinji's hands, Captain Misato Katsuragi hunts for the teenage boy as society crumbles around them.