In the entertainment world, celebrities often show exaggerated versions of themselves to the public, concealing their true thoughts and struggles beneath elaborate lies. Fans buy into these fabrications, showering their idols with undying love and support, until something breaks the illusion. Sixteen-year-old rising star Ai Hoshino of pop idol group B Komachi has the world captivated; however, when she announces a hiatus due to health concerns, the news causes many to become worried. As a huge fan of Ai, gynecologist Gorou Amemiya cheers her on from his countryside medical practice, wishing he could meet her in person one day. His wish comes true when Ai shows up at his hospital—not sick, but pregnant with twins! While the doctor promises Ai to safely deliver her children, he wonders if this encounter with the idol will forever change the nature of his relationship with her.

Hitohito Tadano is an ordinary boy who heads into his first day of high school with a clear plan: to avoid trouble and do his best to blend in with others. Unfortunately, he fails right away when he takes the seat beside the school's madonna—Shouko Komi. His peers now recognize him as someone to eliminate for a chance to sit next to the most beautiful girl in class. Gorgeous and graceful with long, dark hair, Komi is universally adored and immensely popular despite her mysterious persona. However, unbeknownst to everyone, she has crippling anxiety and a communication disorder which prevents her from wholeheartedly socializing with her classmates. When left alone in the classroom, a chain of events forces Komi to interact with Tadano through writing on the blackboard, as if in a one-way conversation. Being the first person to realize she cannot communicate properly, Tadano picks up the chalk and begins to write as well. He eventually discovers that Komi's goal is to make one hundred friends during her time in high school. To this end, he decides to lend her a helping hand, thus also becoming her first-ever friend.

Known for her semblance to the Sadako character of The Ring series, Sawako Kuronuma is given the nickname Sadako and misunderstood to be frightening and malicious like her fictional counterpart, despite having a timid and sweet nature. Longing to make friends and live a normal life, Sawako is naturally drawn to the cheerful and friendly Shouta Kazehaya, the most popular boy in her class. From their first meeting, Sawako has admired Kazehaya's ability to be the center of attention and aspires to be like him. When Kazehaya organizes a test of courage for the entire class and encourages her to attend, Sawako sees this as an opportunity to get along with her classmates, starting with Ayane Yano and Chizuru Yoshida. Through each new encounter and emotion she experiences, Sawako believes that meeting Kazehaya has changed her for the better. Little does Sawako know, her presence has also changed Kazehaya.

Louise Françoise Le Blanc de La Vallière is a self-absorbed mage in a world of wands, cloaks, and royalty. Although she studies at Tristain Academy, a prestigious school for magicians, she has a major problem: Louise is unable to cast magic properly, earning her the nickname of Louise the Zero from her classmates. When the first year students are required to perform a summoning ritual, Louise's summoning results in a catastrophic explosion! Everyone deems this to be yet another failure, but when the smoke clears, a boy named Saito Hiraga appears. Now Louise's familiar, Saito is treated as a slave, forced to clean her clothes and eat off the ground. But when an unfamiliar brand is found etched on Saito's hand from the summoning ritual, it is believed to be the mark of a powerful familiar named Gandalfr. Wild, adventurous, and explosive, Zero no Tsukaima follows Saito as he comes to terms with his new life and as Louise proves that there is more to her than her nickname suggests.