Hunters devote themselves to accomplishing hazardous tasks, all from traversing the world's uncharted territories to locating rare items and monsters. Before becoming a Hunter, one must pass the Hunter Examination—a high-risk selection process in which most applicants end up handicapped or worse, deceased. Ambitious participants who challenge the notorious exam carry their own reason. What drives 12-year-old Gon Freecss is finding Ging, his father and a Hunter himself. Believing that he will meet his father by becoming a Hunter, Gon takes the first step to walk the same path. During the Hunter Examination, Gon befriends the medical student Leorio Paladiknight, the vindictive Kurapika, and ex-assassin Killua Zoldyck. While their motives vastly differ from each other, they band together for a common goal and begin to venture into a perilous world.

Tooru Honda has always been fascinated by the story of the Chinese zodiac that her beloved mother told her as a child. However, a sudden family tragedy changes her life, and subsequent circumstances leave her all alone. Tooru is now forced to live in a tent, but little does she know that her temporary home resides on the private property of the esteemed Souma family. Stumbling upon their home one day, she encounters Shigure, an older Souma cousin, and Yuki, the prince of her school. Tooru explains that she lives nearby, but the Soumas eventually discover her well-kept secret of being homeless when they see her walking back to her tent one night. Things start to look up for Tooru as they kindly offer to take her in after hearing about her situation. But soon after, she is caught up in a fight between Yuki and his hot-tempered cousin, Kyou. While trying to stop them, she learns that the Souma family has a well-kept secret of their own: whenever they are hugged by a member of the opposite sex, they transform into the animals of the Chinese zodiac. With this new revelation, Tooru will find that living with the Soumas is an unexpected adventure filled with laughter and romance.

OZ, a virtual world connected to the internet, has become extremely popular worldwide as a spot for people to engage in a large variety of activities, such as playing sports or shopping, through avatars created and customized by the user. OZ also possesses a near impenetrable security due to its strong encryption, ensuring that any personal data transmitted through the networks will be kept safe in order to protect those who use it. Because of its convenient applications, the majority of society has become highly dependent on the simulated reality, even going as far as entrusting the system with bringing back the unmanned asteroid explorer, Arawashi. Kenji Koiso is a 17-year-old math genius and part-time OZ moderator who is invited by his crush Natsuki Shinohara on a summer trip. But unbeknownst to him, this adventure requires him to act as her fiancé. Shortly after arriving at Natsuki's family's estate, which is preparing for her great-grandmother's 90th birthday, he receives a strange, coded message on his cell phone from an unknown sender who challenges him to solve it. Kenji is able to crack the code, but little does he know that his math expertise has just put Earth in great danger.

Yuugi Mutou is a naïve and lonely high school student who is fascinated by games. While staying with his grandfather, the owner of a game shop, he comes across an ancient Egyption relic known as the Millennium Puzzle. Rumored to grant any wish to those who solve the Puzzle, Yuugi becomes determined to solve it to wish for some friends. After years of struggling, Yuugi manages to complete the puzzle and mysteriously finds that his wish has been fulfilled. Meanwhile, a new card game known as Duel Monsters starts rising in popularity. In this game, players called duelists fight against each other with monsters by using magic and trap cards to foil their opponent's plans. Yuugi quickly becomes skilled at the game and lives a peaceful life with his newfound friends. However, Yuugi's peace is short-lived. The undefeated duelist and egocentric billionaire Seto Kaiba suddenly abducts Yuugi's grandfather, forcing him to duel against the rare Blue Eyes White Dragon'' card. Yuugi is thrown into a new world of fierce battles and the stakes continue to rise as dark forces interfere from the shadows. After unexpectedly defeating Kaiba with the help of his other self—the spirit of a nameless pharaoh—contained in the puzzle, he unofficially becomes the top duelist known as The King of Games. However, this new title will attract covetousness and Yuugi will have to use all his intelligence and willpower in order to protect what he holds the dearest to him.