The Kazama Family—a gang of three wannabe delinquents and close friends, spearheaded by Kenji Kazama, is trying to make a name for themselves at Fujou Academy. On the first day of the term, the gang finds themselves putting out a fire in the Game Development Club. Instead of thanking them, the eccentric club members attack and knock out Kenji's two friends, forcing Kenji to fight for his life. Failing to escape, the gang leader is coerced into joining the Game Development Club. As he settles in, Kenji gets to know the four girls responsible for his provisional membership—student council president and general tyrant Chitose Karasuyama, spirited tomboy Sakura Mizukami, negligent club advisor Minami Oosawa, and the school's infamous shadow leader Roka Shibasaki. Throughout the Game Development Club's constant shenanigans and his desperate attempts to leave the club, Kenji begins to realize that he may be actually enjoying himself.

The Anarchy Sisters, Panty and Stocking, have been kicked out of Heaven for, to put it mildly, misbehaving. Led by a priest named Garterbelt, these angels must buy their way back by exterminating ghosts in Daten City. But this task requires unconventional weapons for these unorthodox angels—they transform their lingerie into weapons to dispatch the spirits. Unfortunately, neither of them take their duties seriously, as they rather spend their time in pursuit of other hobbies: Panty prefers to sleep with anything that walks, and Stocking favors stuffing her face with sweets than hunting ghosts. Follow these two unruly angels as they battle ghosts, an overflow of bodily fluids, and their own tendency to get side-tracked in Panty & Stocking with Garterbelt.

After Mash Burnedead's clash with Magia Lupus, the secret about his powers is now out in the open. The short-lived celebration ends when the Bureau of Magic summons Mash before an audience of Divine Visionaries, who collectively decree Mash should reap the consequences and die. However, an evil shadow organization called Innocent Zero hijacks the inquiry to demand that Mash be kept alive. Mash proves that he is capable of dealing with Innocent Zero, but the Divine Visionaries' verdict remains unchanged. Luckily, Mash finds unexpected allies in Divine Visionary Rayne Ames and Headmaster Wahlberg Baigan, and they successfully defer his execution until Innocent Zero is defeated. Mash is now allowed to live under one condition: he must be selected as the Divine Visionary candidate by the year's end.

Now branded for death and destined to be hunted by demons until the day he dies, Guts embarks on a journey to defy such a gruesome fate, as waves of beasts relentlessly pursue him. Steeling his resolve, he takes up the monstrous blade Dragonslayer and vows to exact vengeance on the one responsible, hunting down the very man he once looked up to and considered a friend. Along the way, he encounters some unlikely allies, such as a small elf named Puck, and Isidro, a young thief looking to learn swordsmanship from the former mercenary. As the ragtag group slowly comes together after having decided to join Guts in his quest, they will face incredible danger unlike anything they have ever experienced before.