In the distant future, humanity has been driven to near-extinction by giant beasts known as Klaxosaurs, forcing the surviving humans to take refuge in massive fortress cities called Plantations. Children raised here are trained to pilot giant mechas known as FranXX—the only weapons known to be effective against the Klaxosaurs—in boy-girl pairs. Bred for the sole purpose of piloting these machines, these children know nothing of the outside world and are only able to prove their existence by defending their race. Hiro, an aspiring FranXX pilot, has lost his motivation and self-confidence after failing an aptitude test. Skipping out on his class' graduation ceremony, Hiro retreats to a forest lake, where he encounters a mysterious girl with two horns growing out of her head. She introduces herself by her codename Zero Two, which is known to belong to an infamous FranXX pilot known as the Partner Killer. Before Hiro can digest the encounter, the Plantation is rocked by a sudden Klaxosaur attack. Zero Two engages the creature in her FranXX, but it is heavily damaged in the skirmish and crashes near Hiro. Finding her partner dead, Zero Two invites Hiro to pilot the mecha with her, and the duo easily defeats the Klaxosaur in the ensuing fight. With a new partner by his side, Hiro has been given a chance at redemption for his past failures, but at what cost?

The Four Cardinal Heroes are a group of ordinary men from modern-day Japan summoned to the kingdom of Melromarc to become its saviors. Melromarc is a country plagued by the Waves of Catastrophe that have repeatedly ravaged the land and brought disaster to its citizens for centuries. The four heroes are respectively bestowed a sword, spear, bow, and shield to vanquish these Waves. Naofumi Iwatani, an otaku, becomes cursed with the fate of being the Shield Hero. Armed with only a measly shield, Naofumi is belittled and ridiculed by his fellow heroes and the kingdom's people due to his weak offensive capabilities and lackluster personality. When the heroes are provided with resources and comrades to train with, Naofumi sets out with the only person willing to train alongside him, Malty Melromarc. He is soon betrayed by her, however, and becomes falsely accused of taking advantage of her. Naofumi then becomes heavily discriminated against and hated by the people of Melromarc for something he didn't do. With a raging storm of hurt and mistrust in his heart, Naofumi begins his journey of strengthening himself and his reputation. Further along however, the difficulty of being on his own sets in, so Naofumi buys a demi-human slave on the verge of death named Raphtalia to accompany him on his travels. As the Waves approach the kingdom, Naofumi and Raphtalia must fight for the survival of the kingdom and protect the people of Melromarc from their ill-fated future.

Corrupt politicians, frenzied nationalists, and other warmongering forces constantly jeopardize the thin veneer of peace between neighboring countries Ostania and Westalis. In spite of their plots, renowned spy and master of disguise Twilight fulfills dangerous missions one after another in the hope that no child will have to experience the horrors of war. In the bustling Ostanian city of Berlint, Twilight dons the alias of Loid Forger, an esteemed psychiatrist. However, his true intention is to gather intelligence on prominent politician Donovan Desmond, who only appears rarely in public at his sons' school: the prestigious Eden Academy. Enlisting the help of unmarried city hall clerk Yor Briar to act as his wife and adopting the curious six-year-old orphan Anya as his daughter, Loid enacts his master plan. He will enroll Anya in Eden Academy, where Loid hopes she will excel and give him the opportunity to meet Donovan without arousing suspicion. Unfortunately for Loid, even a man of his talents has trouble playing the figure of a loving father and husband. And just like Loid is hiding his true identity, Yor—who is an underground assassin known as Thorn Princess—and Anya—an esper who can read people's minds—have no plans to disclose their own secrets either. Although this picture-perfect family is founded on deception, the Forgers gradually come to understand that the love they share for one another trumps all else.

Life in the bustling city of Orario is never dull, especially for Bell Cranel, a naïve young man who hopes to become the greatest adventurer in the land. After a chance encounter with the lonely goddess, Hestia, his dreams become a little closer to reality. With her support, Bell embarks on a fantastic quest as he ventures deep within the city's monster-filled catacombs, known only as the Dungeon. Death lurks around every corner in the cavernous depths of this terrifying labyrinth, and a mysterious power moves amidst the shadows. Even on the surface, survival is a hard-earned privilege. Indeed, nothing is ever certain in a world where gods and humans live and work together, especially when they often struggle to get along. One thing is for sure, though: a myriad of blunders, triumphs and friendships awaits the dauntlessly optimistic protagonist of this herculean tale.