A sinister threat is invading Tokyo: flesh-eating ghouls who appear identical to humans and blend into their population. Reserved college student Ken Kaneki buries his nose in books and avoids the news of the growing crisis. However, the appearance of an attractive woman named Rize Kamishiro shatters his solitude when she forwardly asks him on a date. While walking Rize home, Kaneki discovers she isn't as kind as she first appeared, and she has led him on with sinister intent. After a tragic struggle, he later awakens in a hospital to learn his life was saved by transplanting the now deceased Rize's organs into his own body. Kaneki's body begins to change in horrifying ways, and he transforms into a human-ghoul hybrid. As he embarks on his new dreadful journey, Kaneki clings to his humanity in the evolving bloody conflict between society's new monsters and the government agents who hunt them.

Ken Kaneki has finally come to accept the monstrous, flesh-craving part of himself that he has feared and despised for so long. After escaping captivity and torture, Kaneki joins Aogiri Tree—the very militant ghoul organization that had abducted him, leading his friends to question his true motive and loyalty. As tension between the government and the ghouls continues to rise, the Commission of Counter Ghoul, the government's specialized anti-ghoul agency, has intensified their efforts to completely purge Tokyo of ghouls. This threatens the transient peace of Kaneki's friends and former comrades—the ghouls at the Anteiku coffee shop. Aware of the dangerous situation, Kaneki faces several battles that puts his precious fleeting humanity on the line.

Kazuya Kinoshita is a 20-year-old college student who has a wonderful girlfriend: the bright and sunny Mami Nanami. But suddenly, he doesn't. Without warning, Mami breaks up with him, leaving him utterly heartbroken and lonely. Seeking to soothe the pain, he hires a rental girlfriend through an online app. His partner is Chizuru Mizuhara, who through her unparalleled beauty and cute demeanor, manages to gain Kazuya's affection. But after reading similar experiences other customers had had with Chizuru, Kazuya believes her warm smile and caring personality were all just an act to toy with his heart, and he rates her poorly. Aggravated, Chizuru lambastes him for his shameless hypocrisy, revealing her true pert and hot-tempered self. This one-sided exchange is cut short, however, when Kazuya finds out that his grandmother has collapsed. They dash toward the hospital and find Kazuya's grandmother already in good condition. Baffled by Chizuru's presence, she asks who this girl might be. On impulse, Kazuya promptly declares that they are lovers, forcing Chizuru to play the part. But with Kazuya still hung up on his previous relationship with Mami, how long can this difficult client and reluctant rental girlfriend keep up their act?

Due to a tragic accident, Banri Tada is struck with amnesia, dissolving the memories of his hometown and past. However, after befriending Mitsuo Yanagisawa, he decides to move on and begin a new life at law school in Tokyo. But just as he is beginning to adjust to his college life, the beautiful Kouko Kaga dramatically barges into Banri's life, and their chance meeting marks the beginning of an unforgettable year. After having a glimpse of college life, Banri learns that he is in a new place and a new world—a place where he can be reborn, have new friends, fall in love, make mistakes, and grow. And as he begins to discover who he was, the path he has chosen leads him towards a blindingly bright life that he will never want to forget.