Rika Furude and Satoko Houjou are best friends who have lived in the small village of Hinamizawa for their entire lives. Alongside their other friends, they spend every day together, and every moment is filled with fun and laughter. However, as Rika and Satoko begin to grow older, a life-changing opportunity presents itself to both of them. Rika is determined to follow her dreams and wants Satoko by her side. Although Satoko is hesitant, she decides to walk this path with Rika. However, the realization of her dream forms a rift between them. This leaves the girls living in completely different worlds, with Rika enjoying her new life and making new friends while Satoko grows more and more isolated. Longing to return to the nostalgic days in Hinamizawa, Satoko despairs and wishes things could be changed. Just when she is at wits' end, an encounter with a supernatural entity changes Satoko's perception and imparts new revelations about her best friend Rika. This begins her journey to get the future she desires—by any means necessary.

Youko Nakajima has only ever wanted to be normal. She does what she is asked, gets good grades, is the class president, and even helps her classmates whenever she can—but because of her red hair, she has never fit in. With her pushover attitude, Youko lets classmates take advantage of her, so she has nobody she can really call a friend. But on an otherwise ordinary day, a man who claims to be from another world barges into Youko's classroom and bows before her. This elegant blond-haired man, Keiki, claims that Youko is his master and belongs on the throne of his kingdom. However, their first meeting is cut short as Keiki has been followed by otherworldly beasts called youma. He is able to escape with Youko into his own realm, but two other classmates—Ikuya Asano and Yuka Sugimoto—are caught up in the madness as well. Unfortunately, their troubles have only just begun, as the youma attack leaves them separated from Keiki. Alone in this strange new land, these ordinary students must learn to fend for themselves or die.

Waking up cold and alone in the woods, a nameless man is surrounded by unfamiliar scenes. Without any memories, he is utterly lost until he stumbles upon Kuon—a young girl with animal ears and a tail. She saves him, leading him back to her town while protecting them both from boro-gigiri—giant centipede-like creatures—and a mysterious red slime. After they arrive, she names him Haku after a prominent historical figure from the area. He quickly realizes he is one of a kind—the only one without animal ears and a tail. The two journey to the capital of Yamato, the country in which Kuon lives, meeting more people and making new friends, all the while unknowingly delving deeper into the politics and inner conflicts of Yamato... Utawarerumono: Itsuwari no Kamen follows Haku as he slowly uncovers the secrets of this alien world. He works to solve the mysteries surrounding the red slimes, as well as to stop war from erupting among the nearby countries.

A runaway vehicle driven by Izumi Yasaka, en route to the Public Safety Bureau building, is reported shortly before it crashes into the building. Izumi is a counselor who recently ran away while working at a latent criminal isolation and rehabilitation facility known as Sanctuary. Before Inspectors Mika Shimotsuki and Akane Tsunemori get to interrogate the suspect, a sudden request is issued from the facility to promptly bring Izumi back. Interpreted as a direct order from the Chief and the board at Sanctuary, the Inspectors obey, but insist that Izumi be escorted back personally. Tsunemori intends to investigate further with the rest of the team at the Bureau. Now Inspector Shimotsuki has finally been given the opportunity she had been waiting for—to be the primary investigator on an important case. This case follows Shimotsuki and her team of Enforcers as they uncover the secrets of Sanctuary.