Saddled with amnesia, Yuuri awakens on an interstellar cruiser drifting through space. Unfortunately, a lack of memories is the least of Yuuri's problems. Among the four other crew members is a Gnosia: a Gnos infectee whose goal is the eradication of humanity. The Gnosia appears human in all other respects, so the uninfected have little choice but to vote on whom they suspect to be the enemy, hoping to neutralize the Gnosia by putting them into cold sleep. If the Gnosia survives the vote, they will eliminate one crew member during the cruiser's following warp, when only the Gnosia remains conscious. Voting quickly proves to be an unreliable strategy, and Yuuri is left one-on-one with the Gnosia. Just when all hope seems lost, time seemingly loops back to when Yuuri first awakened. With each time loop, however, conditions aboard the ship change—neither the size of the crew nor the members' identities remain constant. Trapped in both time and space, Yuuri must figure out how to escape the loops and save humanity from the Gnosia.

In a certain kindergarten, Satou Kaya is a notorious troublemaker—so much so that several of her teachers have already quit from the stress that comes with managing her. She constantly prevents other children from playing, reading their favorite books, or even going to the restroom—at least, that is what it looks like from the outside. When a new kindergarten teacher, Chie Hasumi, is assigned to Kaya, she discovers that Kaya actually protects other kids from evil spirits! With this newfound knowledge, Chie places her trust in Kaya to keep the class safe. However, Chie soon realizes that, while Kaya protects her friends, there may be something at home Kaya herself needs protection from.

High school girl duo Popuko and Pipimi are back and more unhinged than ever after their initial efforts to create a full-fledged anime production were met with a great reception. With no regard for their audience, they continue to live their reckless everyday lives consisting of comedy skits and parodies of epic proportions. No one is immune to the effects of their antics—including hapless live actor Shouta Aoi, who is on the run and stuck trying to be a hero in the wrong series.

Tatsumiyajima is the central island in the middle of a small cluster of islands, in a sleepy backwater of the Japanese isles. Not much happens there, and the island's young people go to school knowing that their lives are likely to remain peaceful and undisturbed. Or so they have been taught... but the truth is different. The fate of mankind is on the line, and Tatsumiyajima is the last line of defense against a hostile and incomprehensible enemy. At the center of it all, fighting for Humanity's continued existence, is the giant robot Fafner, the dragon that guards this final treasure of mankind. (Source: ANN)