The bustling metropolis of Kansai, where cybernetic screens litter the neon landscape, may seem like a technological utopia at first glance. But in the dark alleys around the brightly-lit buildings, an unforgiving criminal underbelly still exists in the form of fugitives known as Akudama. No stranger to these individuals, Kansai police begin the countdown to the public execution of an infamous Akudama Cutthroat, guilty of killing 999 people. However, a mysterious message is sent to several elite Akudama, enlisting them to free Cutthroat for a substantial amount of money. An invisible hand seeks to gather these dangerous personas in one place, ensuring that the execution is well underway to becoming a full-blown bloodbath.

In Ikebukuro, the lives of its citizens continue intertwining with each other as if their fates are predestined. Mikado Ryuugamine is now one step closer to his goal of living an exciting life, and in turn, delves deeper into the darker side of Ikebukuro. After gaining absolute control over a former rival, he uses his newfound power as he pleases, purging the Dollars from the inside to mold it into the ideal organization. This proves to be as challenging as it sounds as Mikado must now deal with unwanted outside interference, most notably a re-emerging and dearly missed friend. Meanwhile, Izaya Orihara still has some schemes up his sleeve, although a rival information exchange center has proven to be quite the hindrance, lurking within everyone's favorite downtown district. Undoubtedly, sooner or later, chaos will strike again.

Daisuke Kanbe, a man of extraordinary wealth, is assigned to the Modern Crime Prevention Headquarters as a detective. It is there that he gets partnered with Haru Katou, a humane detective who values justice above all. The two are polar opposites, and their morals clash time and time again. Haru despises Daisuke for using monetary wealth to solve cases, as he believes that money isn't everything. The two will have to combine their efforts, however, to solve the mysteries that are coming their way.

As Mikado Ryuugamine continues to purge the Dollars from within in accordance with his warped sense of justice, Masaomi Kida hopes to bring his friend back to his senses by bringing the Yellow Scarves together once more. Little do they know that a far more dominant force is about to enter their struggle for power, one that their friend Anri Sonohara is all too familiar with. Meanwhile, the group that has gathered at Shinra Kishitani's apartment realizes that they are on the brink of something life-changing, an event that will throw Ikebukuro into a spiral of confusion. Their anxiety is realized when reports of Celty's head being found in public start to appear all over the news as Kasane Kujiragi begins to make her move. Gone are the brief periods of tranquility as the current turmoil sets the stage for one final performance in this thrilling conclusion to the story of Ikebukuro's finest.