The Noblesse Cadis Etrama di Raizel, also known as Rai, is enrolled in Ye Ran High School by his servant Frankenstein to stay hidden from the sights of the Union, a mysterious organization out for Rai's blood. Rai commences his life as a student, making himself familiar with his classmates and the daily activities of humans. However, his new life is far from peaceful, and Rai is soon forced to save his new friends from the hands of the Union that had abducted them. Meanwhile, M-21—a Union agent gone rogue during Rai's rescue operation—joins the Ye Ran High School security staff after a proposition by the school's director, who happens to be none other than Frankenstein himself. On the surface, M-21 is a prim and proper employee, but in truth he is shackled by his former ties to the Union and the inevitable consequences of betraying the organization. To further complicate matters, Nobles Regis K. Landegre and Seira J. Loyard enroll in the same school to investigate the Noblesse. While the Union conducts a manhunt for M-21 to extract clues regarding their missing agents, Rai is forced to keep his identity hidden while protecting all that he holds dear.

Great Britain is ablaze with news of a so-called Lord of Crime, a criminal mastermind responsible for the downfall of several unruly nobles. In truth, the Lord of Crime is not an individual, but rather a group consisting of William James Moriarty and his two brothers, Louis and Albert. Together, they wish to destroy everything rotten about their current world and create a new, fair society for all. To accomplish their goal, they must commit criminal acts, which the great detective Sherlock Holmes and his partner, John H. Watson, cannot abide by. A dangerous cat and mouse game begins between the Lord of Crime and Sherlock, with each trying to outwit the other. Yet Sherlock, despite his skills, has no idea that his foe is right under his nose. Involved with both parties is a woman named Irene Adler, who is as beautiful as she is cunning. No stranger to scandal, Irene has embroiled herself in one that may be too big even for her, as the classified documents she stole could shake the very foundations of the British Empire. Can Irene be saved, or does a deadly future await her?

Under the doctrines of Quirk Doomsday Theory, the ideological group Humarise is convinced that all humans with quirks are diseased and must be eradicated. In order to rebuild the world, the group's extremists have constructed a lethal device known as a Trigger Bomb that causes people with quirks to lose control and die. Their leader, Flect Turn, evades capture from the Pro Heroes deployed around the world. During his work study in the country of Otheon with Japan's number one Pro Hero, Izuku Deku Midoriya is accused of a crime he did not commit. Unintentionally involving Roddy Soul, a local, Deku soon finds himself on the run with the boy. It is now up to Rody, Deku, and Deku's classmates to stop the Trigger Bomb plot set in motion by Flect, all while eluding the other persistent members of Humarise.

For the Takakura family, destiny is an ever-spinning wheel, pointing passionately in their direction with equal tides of joy and sorrow before ticking on to the next wishmaker. With their parents gone, twin brothers Kanba and Shouma live alone with their beloved little sister Himari, whose poor health cannot decline any further. On the day Himari is given permission to temporarily leave the hospital, her brothers take her out to the aquarium to celebrate, where the family's supposed fate is brought forth with her sudden collapse. However, when Himari is inexplicably revived by a penguin hat from the aquarium's souvenir shop, the hand of fate continues to tick faithfully forward. With her miraculous recovery, though, comes a cost: there is a new entity within her body, whose condition for keeping her fate at bay sends the boys on a wild goose chase for the mysterious Penguin Drum. In their search, the boys will have to follow the threads of fate leading from their own shocking past and into the lives of other wishmakers vying for the Penguin Drum, all hoping to land upon their chosen destiny.