During his school computer class, Saneatsu Narita is presented with a strange screen posing a yes-or-no question that quickly disappears. The next day, Saneatsu wakes up to a world where everyone, save for himself and a few others, is dead. An announcement from a mysterious figure known only as the Emperor begins to shed light on the situation. The question that Saneatsu saw on the screen is part of a game called Tasuuketsu. Every day, the survivors will see a question appear on a screen, and answering it will determine who lives to see the next day. Responding the same as the majority will guarantee death, and the last player standing will earn the right to meet the Emperor. Saneatsu resolves to beat the Emperor at their own game, making use of the hidden envelopes containing powers that can aid the players. With the help of his small group of friends, Saneatsu must avoid falling into the machinations of the other players and win this wicked game.

After narrowly escaping a deathtrap, a dazed Ning Yuan finds himself confined by a menacing gangster, He Zhiyang, alongside hysterical doctor, Su Jin. However, this proves to be the least of his concerns as he comes to terms with the group's newfound desperate situation: they are trapped on an isolated island that harbors malignant viruses, horrid mutations, and hostile tribes. Meanwhile, another group of individuals in the same vicinity happen to face the same predicament. Forced to put aside their differences and come together to fight their way to freedom, the two groups of stranded victims must resist their personal motivations which threaten to get the better of them.

College student Nao Kanzaki has always adhered to her name's meaning: foolishly honest. However, after opening an unsolicited package containing one hundred million yen, she inadvertently accepts an invitation for the Liar Game. In this tournament, contestants are encouraged to betray and deceive their opponents to gain a massive amount of cash; conversely, losing will incur a lifetime debt. With all hopes lost, her only option left is to seek help from a con artist. On that same day, the infamous swindler Shinichi Akiyama is finally released from jail. This former psychology student is known for single-handedly bankrupting an entire company, and Nao believes he is her only chance at escaping her dire situation. At first, Shinichi is hesitant to commit another crime, ignoring Nao and her request. But after seeing her desperation and persistence, he agrees to assist her. In this fraudulent world, Nao and Shinichi have their own motives. Yet, soon they see the true nature of not only the game, but also everyone involved.

In the future (subsequent to the events of the television series) Kate, Rose, Rachel and Claire divide their immortal lives between study and vigilantism. Their past link to the red garden on Roosevelt Island comes back to haunt them after mysterious transfer students Louise and Edgar seek out their friendship.