Eighth-grader Shigeo Mob Kageyama has tapped into his inner wellspring of psychic prowess at a young age. But the power quickly proves to be a liability when he realizes the potential danger in his skills. Choosing to suppress his power, Mob's only present use for his ability is to impress his longtime crush, Tsubomi, who soon grows bored of the same tricks. In order to effectuate control on his skills, Mob enlists himself under the wing of Arataka Reigen, a con artist claiming to be a psychic, who exploits Mob's powers for pocket change. Now, exorcising evil spirits on command has become a part of Mob's daily, monotonous life. However, the psychic energy he exerts is barely the tip of the iceberg; if his vast potential and unrestrained emotions run berserk, a cataclysmic event that would render him completely unrecognizable will be triggered. The progression toward Mob's explosion is rising and attempting to stop it is futile.

After successfully passing his Provisional Hero License exam, Izuku Deku Midoriya seeks out an extracurricular internship with a professional hero agency. At the recommendation of his mentor All Might, Midoriya lands a position under All Might's former sidekick, Sir Nighteye, now a famous hero in his own right. As Midoriya's classmates further their own abilities through various internships, up-and-coming villain Kai Chisaki utilizes his terrifying powers to gather favor in the criminal underworld. Known by the moniker Overhaul, Chisaki's ambitions collide with the League of Villains and its leader, Tomura Shigaraki. Through his work with Sir Nighteye, Midoriya discovers Chisaki's crime syndicate and the villain's hostile relationship with a mysterious young girl named Eri. Fearing for the child's safety, Midoriya and his upperclassman Mirio Toogata must work together to put an end to Chisaki's reign of terror.

If not for his ability to take over people's mind and body, Yuu Otosaka would be an ordinary high school student. Though it only lasts for five seconds at a time, Yuu's mysterious power allowed him to cheat his way to the top of his class and enter a prestigious high school, where he continues his dishonest acts. His shenanigans are eventually stopped by Nao Tomori—the headstrong student council president from Hoshinoumi Academy—who sees through his deceit. Through coercion, Nao convinces Yuu to transfer to Hoshinoumi and join the student council. Hoshinoumi Academy is secretly an institution created for adolescents who possess supernatural abilities—with the student council serving as a means of locating those who abuse their powers. With Yuu begrudgingly assisting in council affairs, the group sets out to find and protect new ability users from harm. However, as they further investigate the abilities, their findings entangle them in far more complicated matters than they could ever imagine.

After the murder of her father, Ryuuko Matoi has been wandering the land in search of his killer. Following her only lead—the missing half of his invention, the Scissor Blade—she arrives at the prestigious Honnouji Academy, a high school unlike any other. The academy is ruled by the imposing and cold-hearted student council president Satsuki Kiryuuin alongside her powerful underlings, the Elite Four. In the school's brutally competitive hierarchy, Satsuki bestows upon those at the top special clothes called Goku Uniforms, which grant the wearer unique superhuman abilities. Thoroughly beaten in a fight against one of the students in uniform, Ryuuko retreats to her razed home where she stumbles across Senketsu, a rare and sentient Kamui, or God Clothes. After coming into contact with Ryuuko's blood, Senketsu awakens, latching onto her and providing her with immense power. Now, armed with Senketsu and the Scissor Blade, Ryuuko makes a stand against the Elite Four, hoping to reach Satsuki and uncover the culprit behind her father's murder once and for all.