Taking a break from his time as a teacher, the powerful slime Rimuru Tempest returns to his kingdom, eponymously named Tempest, just in time to begin negotiations with a nearby nation—the Kingdom of Eurazania. While the negotiations are anything but peaceful, they do end successfully, allowing Rimuru to return and finish teaching. When trying to again return to Tempest, this time permanently, Rimuru is stopped by a mysterious figure who is somehow able to constrain the many magical abilities he has at his disposal. In Tempest, the situation is even worse. A group of unknown humans has invaded the land and are assaulting its citizens, both influential and innocent. They are not just trying to bring harm either—they have the intent to kill. Can Rimuru overcome his powerful and dangerous foe and return to Tempest before it is too late?

The greedy samurai lord Daigo Kagemitsu's land is dying, and he would do anything for power, even renounce Buddha and make a pact with demons. His prayers are answered by 12 demons who grant him the power he desires by aiding his prefecture's growth, but at a price. When Kagemitsu's first son is born, the boy has no limbs, no nose, no eyes, no ears, nor even skin—yet still, he lives. This child is disposed of in a river and forgotten. But as luck would have it, he is saved by a medicine man who provides him with prosthetics and weapons, allowing for him to survive and fend for himself. The boy lives and grows, and although he cannot see, hear, or feel anything, he must defeat the demons that took him as sacrifice. With the death of each one, he regains a part of himself that is rightfully his. For many years he wanders alone, until one day an orphan boy, Dororo, befriends him. The unlikely pair of castaways now fight for their survival and humanity in an unforgiving, demon-infested world.

After a stern yet compelling speech by Otto Suwen, Subaru Natsuki solemnly swears that he will successfully make it through this timeline and save everyone he can along the way. The first step toward achieving this goal is to help Emilia work through her past; however, that is easier said than done. Feeling as if she has been lied to by everyone around her, it will be difficult for Emilia to trust anyone, even Subaru, her self-proclaimed knight. Re:Zero kara Hajimeru Isekai Seikatsu 2nd Season Part 2 presents the culmination of Subaru's experiences with the Sanctuary and its people, along with his unwillingness to give up hope on saving them.

Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.