Though he has successfully repelled the latest Wave of Catastrophe, Naofumi Iwatani—the Shield Hero—has no time to rest. Naofumi is spurred back into action when Queen Mirelia Q Melromarc tells him that the three other Cardinal Heroes have disappeared without a trace, and she tasks him with finding them. With no clues regarding their whereabouts, Naofumi tackles a more pressing issue: the worsening slave trade of demi-humans. Determined to right this injustice, he and his friends find their way to Zeltoble, the country of mercenaries, where the illegal sale of demi-humans has become a lucrative business. To gather money to free the slaves, Naofumi and his comrades disguise themselves and take part in underground coliseum brawls, purposely throwing matches to manipulate the odds and eventually secure an enormous payout. However, with the threat of another Wave of Catastrophe looming on the horizon, the Shield Hero must stick to his mission of finding the missing heroes if he wants to protect those he loves.

Thirty years ago, a new race of flame-wielding mutants suddenly appeared, destroying a large portion of humanity. These so-called “Burnish” have continued to appear at random, leaving a trail of death and destruction in their wake. The autonomous republic of Promepolis is a thriving nation thanks to the incredible efforts of their leader, Kray Foresight, against the Burnish. A team of firefighters known as the Burning Rescue is tasked with stopping these horrifying monsters, using the most performant technology available thanks to their incredible mechanic Lucia Fex. Galo Thymos is an energetic young man, who considers Foresight his hero for saving his life and is the rescue team's most recent recruit. A terrorist group calling themselves Mad Burnish has been causing havoc all over the nation. After an encounter with Mad Burnish leader Lio Fotia, Galo sets out on his fated journey to find the truth about these mutants, ultimately leading him to question everything he previously held to be true.

In the world of Duel Monsters, a new generation of duelists await their turn to bid for the highest title: The King of Games. As an aspiring duelist, the happy-go-lucky Juudai Yuuki enrolls at the Duel Academy, a reputable institution tasked with nurturing these potential challengers. On his first day, however, Juudai's laid back and careless attitude causes him to arrive late to his entrance exam. There, he stumbles upon a familiar figure who entrusts him the Winged Kuriboh, a card which becomes Judai's new partner. Soon, he begins living as a duelist—but will destiny and darkness bend his reality into something beyond his imagination? Yu☆Gi☆Oh!: Duel Monsters GX follows the story of Juudai as he strives to fulfill his goal of becoming the next King of Games. As they are thrust into countless unprecedented circumstances, one thing is for sure for Juudai and his friends—there will never be a dull moment at the Duel Academy!

Together with his talented aides, the Realist Hero Kazuya Souma continues his quest of reinvigorating the Elfrieden Kingdom through administrative reform. Having successfully conquered Van—the capital city of the Principality of Amidonia—Kazuya now faces the envoy from Gran Chaos Empire, who wishes to impose punishment for breaching the ban on war established by the Mankind Declaration Treaty. Despite the dire situation, Kazuya sees a path to avoid unnecessary conflict whilst gaining new allies. With his plan being seemingly perfect, the only barrier to success is gaining approval from the envoy.