In the town of Kamisu 66, 12-year-old Saki Watanabe has just awakened to her psychic powers and is relieved to rejoin her friends—the mischievous Satoru Asahina, the shy Mamoru Itou, the cheerful Maria Akizuki, and Shun Aonuma, a mysterious boy whom Saki admires—at Sage Academy, a special school for psychics. However, unease looms as Saki begins to question the fate of those unable to awaken to their powers, and the children begin to get involved with secretive matters such as the rumored Tainted Cats said to abduct children. Shinsekai yori tells the unique coming-of-age story of Saki and her friends as they journey to grow into their roles in the supposed utopia. Accepting these roles, however, might not come easy when faced with the dark and shocking truths of society, and the impending havoc born from the new world.

To be quiet and do as you're told, that's the cowardly choice. These are the words of Junk Dog, an underground fighter of Megalo Box, an evolution of boxing that utilizes mechanical limbs known as Gear to enhance the speed and power of its users. Despite the young man's brimming potential as a boxer, the illegal nature of his participation forces him to make a living off of throwing matches as dictated by his boss Gansaku Nanbu. However, this all changes when the Megalo Box champion Yuuri enters his shabby ring under the guise of just another challenger. Taken out in a single round, Junk Dog is left with a challenge: If you're serious about fighting me again, then fight your way up to me and my ring. Filled with overwhelming excitement and backed by the criminal syndicate responsible for his thrown matches, Junk Dog enters Megalonia: a world-spanning tournament that will decide the strongest Megalo Boxer of them all. Having no name of his own, he takes on the moniker of Joe as he begins his climb from the very bottom of the ranked list of fighters. With only three months left to qualify, Joe must face off against opponents the likes of which he has never fought in order to meet the challenge of his rival.

The year is 2071. Humanity has been pushed to the brink of extinction following the emergence of man-eating monsters called Aragami that boast an immunity to conventional weaponry. They ravaged the land, consuming almost everything in their path and leaving nothing in their wake. To combat them, an organization named Fenrir was formed as a last-ditch effort to save humanity through the use of God Eaters—special humans infused with Oracle cells, allowing them to wield the God Arc, the only known weapon capable of killing an Aragami. One such God Eater is Lenka Utsugi, a New-Type whose God Arc takes the form of both blade and gun. Now, as one of Fenrir's greatest weapons, Lenka must master his God Arc if he is to fulfill his desire of wiping out the Aragami once and for all. The monsters continue to be born en masse while the remnants of humanity struggle to survive the night. Only God Eaters stand between the Aragami and complete and total annihilation of the human race.

Within the domed city of Romdo lies one of the last human civilizations on Earth. Thousands of years ago, a global ecological catastrophe doomed the planet; now, life outside these domes is virtually impossible. To expedite mankind's recovery, AutoReivs, humanoid-like robots, have been created to assist people in their day-to-day lives. However, AutoReivs have begun contracting an enigmatic disease called the Cogito Virus, which grants them self-awareness. Re-l Mayer, the granddaughter of Romdo's ruler, is assigned to investigate this phenomenon alongside her AutoReiv partner, Iggy. But what begins as a routine investigation quickly spirals into a conspiracy as Re-l is confronted by humanity's darkest sins. Elsewhere in Romdo, an AutoReiv specialist by the name of Vincent Law must also face his demons when surreal events begin occurring around him. Re-l, Iggy, Vincent, and the child AutoReiv named Pino will form an unlikely faction as they struggle to uncover Romdo's mysteries and discover the true purpose of the mythical beings called Proxies.