Keita Amano is a typical high school gamer living out an average student's life. One day, however, he has an unexpected meeting with the cutest girl in school that makes him want to disappear without a trace! This girl, Karen Tendou, is an exemplary student who is proclaimed to be the school's idol. She discovers that Amano is a gamer, and this newfound knowledge incites a passionate desire within her to recruit him into the game club. Upon visiting the club, Amano is forcefully made aware of a side to gaming wildly different than the one he loves so dearly. Tendou's interest in Amano begins shaking up what was once an uneventful life, filling it with spontaneity, awkwardness, and a little bit of mayhem. As a result, every day becomes a comical battle for Amano's sanity as he tries to adapt to these wild, unexpected changes.

After her boyfriend breaks up with her for another girl, college student Akane Kinoshita wrestles with a broken heart and the memories he left behind. Loading up Forest of Savior, the MMO they used to play together, she forms a plan to get back at her ex-boyfriend through an in-person event for the game. In the process, she runs into someone unexpected: Akito Yamada, a gaming legend who just happens to be her guildmate. Desperate for support, Akane ropes the asocial Yamada into helping with her scheme and lending her a shoulder to cry on. The differences between Akane and Yamada soon become apparent as they spend time together, yet they cannot help but notice each other's inner qualities. As the two gain more experience with one another in and out of the game, their tentative acquaintance may level up in a way neither expects.

Fumiya Tomozaki is Japan's best player in the online game Attack Families, commonly known as Tackfam. Despite holding such a revered title, a lack of social skills and amiability causes him to fall short in his everyday high school life. Failing to have any friends, he blames the convoluted mechanics and unfair rules of life, forcing him to give up and proclaim himself a bottom-tier character in this game. After a fateful meeting with another top-tier Tackfam player, Fumiya is shocked to discover the player's true identity—Aoi Hinami, a popular, smart, and sociable classmate who is the complete opposite of himself. Aoi, surprised at how inept Fumiya is at everything besides Tackfam, decides to assist him in succeeding in what she calls the greatest game of them all. Through the gruesome ordeals of social interactions and relationships, Fumiya begins to advance tiers in the glorious game of life.

The Mutou family leads a peaceful life: Kouichirou works at a construction site and his wife Mari is returning from an overseas trip. Their daughter Ayumu has just finished her track practice while their son Gou is playing video games at home. However, life as they know it is flipped upside down when a calamitous earthquake strikes the entire Japanese archipelago—obliterating the face of the country in an instant. With society crumbling around them and their nation gradually sinking into the ocean, the Mutou family must band together to survive the catastrophe. Treading the near-apocalyptic setting, they struggle not only to stay alive, but also to learn the difficulty of coping with loss.