When an Emishi village is attacked by a fierce demon boar, the young prince Ashitaka puts his life at stake to defend his tribe. With its dying breath, the beast curses the prince's arm, granting him demonic powers while gradually siphoning his life away. Instructed by the village elders to travel westward for a cure, Ashitaka arrives at Tatara, the Iron Town, where he finds himself embroiled in a fierce conflict: Lady Eboshi of Tatara, promoting constant deforestation, stands against Princess San and the sacred spirits of the forest, who are furious at the destruction brought by the humans. As the opposing forces of nature and mankind begin to clash in a desperate struggle for survival, Ashitaka attempts to seek harmony between the two, all the while battling the latent demon inside of him. Princess Mononoke is a tale depicting the connection of technology and nature, while showing the path to harmony that could be achieved by mutual acceptance.

A millennium has passed since the catastrophic nuclear war named the Seven Days of Fire, which destroyed nearly all life on Earth. Humanity now lives in a constant struggle against the treacherous jungle that has evolved in response to the destruction caused by mankind. Filled with poisonous spores and enormous insects, the jungle spreads rapidly across the Earth and threatens to swallow the remnants of the human race. Away from the jungle exists a peaceful farming kingdom known as the Valley of the Wind, whose placement by the sea frees it from the spread of the jungle's deadly toxins. The Valley's charismatic young princess, Nausicaä, finds her tranquil kingdom disturbed when an airship from the kingdom of Tolmekia crashes violently in the Valley. After Nausicaä and the citizens of the Valley find a sinister pulsating object in the wreckage, the Valley is suddenly invaded by the Tolmekian military, who intend to revive a dangerous weapon from the Seven Days of Fire. Now Nausicaä must fight to stop the Tolmekians from plunging the Earth into a cataclysm which humanity could never survive, while also protecting the Valley from the encroaching forces of the toxic jungle.

Middle school student Mirai Onozawa is dissatisfied with her family circumstances and, in a moment of frustration, wishes to tear everything apart. Unfortunately, these destructive thoughts seem to come true in the form of a magnitude 8.0 earthquake just a few moments later. When summer vacation begins, Mirai reluctantly takes her younger brother Yuuki to Odaiba, where a robot exhibition that he wanted to go to is being held. However, while they are in the exhibition center, the fury of a major earthquake shakes the Kanto region; helpless, both kids witness the devastating power of this natural disaster as it brings the city to its knees. In its aftermath, they stumble upon Mari Kusakabe, a motorcyclist and single mother who decides to help the young siblings. Aiming to return to their homes and reunite with their families, the group sets off on a long and hard journey through the decimated city.

The Mutou family leads a peaceful life: Kouichirou works at a construction site and his wife Mari is returning from an overseas trip. Their daughter Ayumu has just finished her track practice while their son Gou is playing video games at home. However, life as they know it is flipped upside down when a calamitous earthquake strikes the entire Japanese archipelago—obliterating the face of the country in an instant. With society crumbling around them and their nation gradually sinking into the ocean, the Mutou family must band together to survive the catastrophe. Treading the near-apocalyptic setting, they struggle not only to stay alive, but also to learn the difficulty of coping with loss.