Sixteen sentient races inhabit Disboard, a world overseen by Tet, the One True God. The lowest of the sixteen—Imanity—consists of humans, a race with no affinity for magic. In a place where everything is decided through simple games, humankind seems to have no way out of their predicament—but the arrival of two outsiders poses a change. On Earth, stepsiblings Sora and Shiro are two inseparable shut-ins who dominate various online games under the username Blank. While notorious on the internet, the pair believe that life is merely another dull game. However, after responding to a message from an unknown user, they are suddenly transported to Disboard. The mysterious sender turns out to be Tet, who informs them about the world's absolute rules. After Tet leaves, Sora and Shiro begin their search for more information and a place to stay, taking them to Elkia—Imanity's only remaining kingdom. There, the duo encounters Stephanie Dola, an emotional girl vying for the kingdom's sovereignty. In desperation, she attempts to regain her father's throne, but her foolhardiness makes her goal unachievable. Inspired by the girl's motivation and passion, Sora and Shiro decide to aid Stephanie in getting Elkia back on its feet, ultimately aiming to become the new rulers of the enigmatic realm.

Asta and Yuno were abandoned at the same church on the same day. Raised together as children, they came to know of the Wizard King—a title given to the strongest mage in the kingdom—and promised that they would compete against each other for the position of the next Wizard King. However, as they grew up, the stark difference between them became evident. While Yuno is able to wield magic with amazing power and control, Asta cannot use magic at all and desperately tries to awaken his powers by training physically. When they reach the age of 15, Yuno is bestowed a spectacular Grimoire with a four-leaf clover, while Asta receives nothing. However, soon after, Yuno is attacked by a person named Lebuty, whose main purpose is to obtain Yuno's Grimoire. Asta tries to fight Lebuty, but he is outmatched. Though without hope and on the brink of defeat, he finds the strength to continue when he hears Yuno's voice. Unleashing his inner emotions in a rage, Asta receives a five-leaf clover Grimoire, a Black Clover giving him enough power to defeat Lebuty. A few days later, the two friends head out into the world, both seeking the same goal—to become the Wizard King!

The final hour of the popular virtual reality game Yggdrasil has come. However, Momonga, a powerful wizard and master of the dark guild Ainz Ooal Gown, decides to spend his last few moments in the game as the servers begin to shut down. To his surprise, despite the clock having struck midnight, Momonga is still fully conscious as his character and, moreover, the non-player characters appear to have developed personalities of their own! Confronted with this abnormal situation, Momonga commands his loyal servants to help him investigate and take control of this new world, with the hopes of figuring out what has caused this development and if there may be others in the same predicament.

Life in the bustling city of Orario is never dull, especially for Bell Cranel, a naïve young man who hopes to become the greatest adventurer in the land. After a chance encounter with the lonely goddess, Hestia, his dreams become a little closer to reality. With her support, Bell embarks on a fantastic quest as he ventures deep within the city's monster-filled catacombs, known only as the Dungeon. Death lurks around every corner in the cavernous depths of this terrifying labyrinth, and a mysterious power moves amidst the shadows. Even on the surface, survival is a hard-earned privilege. Indeed, nothing is ever certain in a world where gods and humans live and work together, especially when they often struggle to get along. One thing is for sure, though: a myriad of blunders, triumphs and friendships awaits the dauntlessly optimistic protagonist of this herculean tale.