Hanamichi Sakuragi, infamous for his temper, massive height, and fire-red hair, enrolls in Shohoku High, hoping to finally get a girlfriend and break his record of being rejected 50 consecutive times in middle school. His notoriety precedes him, however, leading to him being avoided by most students. Soon, after certain events, Hanamichi is left with two unwavering thoughts: I hate basketball, and I desperately need a girlfriend. One day, a girl named Haruko Akagi approaches him without any knowledge of his troublemaking ways and asks him if he likes basketball. Hanamichi immediately falls head over heels in love with her, blurting out a fervent affirmative. She then leads him to the gymnasium, where she asks him if he can do a slam dunk. In an attempt to impress Haruko, he makes the leap, but overshoots, instead slamming his head straight into the blackboard. When Haruko informs the basketball team's captain of Hanamichi's near-inhuman physical capabilities, he slowly finds himself drawn into the camaraderie and competition of the sport he had previously held resentment for.

The dispassionate, transforming assassin Golden Darkness returns to peer deeper into the mysteries surrounding her new life, while a sinister Nemesis manipulates her younger sister Mea from the shadows. Along with their newly discovered mother, Tearju, this previously estranged family quickly becomes the center of everyone's attention. On the other hand, Princess Momo's Harem Plan stands on shaky ground amidst Rito's inability to confess to his longtime crush Haruna, who has grown feelings of her own. But things aren't as peaceful as they seem; an evil force looms amidst the innocuous commotion, threatening to eclipse the love, happiness, and friendship of Rito and his harem. Only the light of love can hope to banish the shadow.

Ever since he lost his family in an explosion, Mirai Kakehashi has lived a life of pain and despair. Every day, he endures abuse at the hands of the relatives who took him in. As his anguish steadily chips away at his will to live, he is eventually pushed to the brink. Prepared to throw it all away, he stands on the edge of a precipice and takes the leap. However, instead of falling to his death, he enters a trance where he meets a winged being who claims to be his guardian angel. Named Nasse, the angel offers him two priceless abilities and convinces him to go on living. When Mirai experiences the marvel of his new powers firsthand, he gets a taste of the freedom that was locked away from him for so long. Armed with Nasse's gifts, Mirai is flung into a showdown with 12 other individuals, one of which will be chosen to become the next God. In stark contrast to when he wanted to end his life, Mirai is now prepared to do whatever it takes to protect his bleak chance at happiness, lest it be wrenched from his grasp forever.

As a young child, Aizawa Yuuichi had often visited his cousin in the city; however, something drastic happened to keep him away for seven long years. Now, Yuuichi returns, his memories of those days are simply gone. Settling into the wintry town, Yuuichi comes across several young girls, all of whom are connected to his past. As he befriends them and continues to interact with them, the long forgotten memories from his childhood begin to resurface...