Once upon a time, the demon lord Rchimedes spread terror throughout the world, until he was eventually sealed away by the legendary hero Creasion. Since then, a thousand years have passed peacefully. However, a mysterious hole has opened up between the demon and human spheres, and countless demons have surged into the human realm once more. Coming to the conclusion that Rchimedes would soon return to wreak havoc, a human king summons the possible descendants of the legendary hero—all 75 of them. Unfortunately, after so long, it was too difficult to pinpoint his true descendants. Among the lionhearted prospects is the amateur adventurer Alba Frühling. His skills may not be top-notch, but he is accompanied by the talented soldier Ross, who helps the young hero whenever he is in a pinch...or at least, he is supposed to. Though undoubtedly a skilled warrior, Ross is actually both sarcastic and sadistic, and hence revels in Alba's suffering. Senyuu. is a comedic adventure following the unlikely duo as they struggle in their endeavor to defeat the demon lord, meeting various eccentrics along the way.

Upon meeting for the first time, undefeated street fighter Daimon, Masaru and renegade Digimon Agumon become friends in the most natural way possible for the knuckleheaded duo—by fighting their hearts out. The self-proclaimed ultimate team are recruited by a secret government organization called the Digimon Data Squad, or DATS, who had witnessed an unbelievable human fighting blow for blow with a Digimon. Their primary objective is investigating mysterious problems caused by Digimon entering the real world, and the world is currently in the midst of a crisis with Digimon appearing at an unprecedented rate. Embarking on various missions with DATS, Daimon and Agumon become colleagues with adolescent genius Touma Norstein and his Digimon partner Gaoman, along with the kind-hearted Yoshino Yoshi Fujeda and her Digimon partner Lalamon. As the group continues to investigate the rapid increase of Digimon in their world, a darker truth begins to surface, and it is up to Daimon, Agumon, and their friends to get to the bottom of things.

Mitsunari Tokugawa, the organizer of the historic Tokugawa underground fighting ring, has created a tournament featuring 38 of the world's best fighters, many of whom are grandmasters in their respective form of martial arts. With the exception of weapons, anything goes in Tokugawa's ring so that each fighter is able to showcase their true power and strongest secret moves. Baki Hanma earned a place in the tournament due to his status as the reigning champion of Tokugawa's fighting ring. Will he be able to come out on top?

While taking a ferry to Fuuka Academy, new students Mai Tokiha and her sickly younger brother, Takumi, spot a girl adrift on the water. Shortly after bringing her aboard, the ferry comes under attack from an assailant who summons a mechanical monster. Despite still recovering from her injuries, Mikoto Minagi fends off the monster using a supernatural sword. Mai soon discovers that Mikoto is a fellow Fuuka Academy student with abilities called HiME (Highly-advanced Materializing Equipment). Female students with HiME are responsible for defending the academy and the local city from the monstrous Orphans. After several incidents at the school involving battles against these mysterious creatures, Mai learns that she is a HiME herself and is capable of summoning a Child, a mechanical creature capable of great utility and firepower. Now burdened with new responsibilities, Mai joins 12 other HiME as they safeguard the school from a threat they know little about all while protecting the ones closest to them.