Tucked in the mountains near the elite Kunugigaoka Middle School lies a small derelict building that houses the delinquents and dropouts of Class 3-E. Looked down upon by their peers, the students in this class appear to have little hope in advancing their academic careers. That is, until the national government tasks them with eliminating the greatest threat to their planet: their new teacher. Having already destroyed the moon, the octopus-like professor—dubbed Koro-sensei—has now threatened to destroy the Earth by March of the following year. In light of their mission, the students have found that killing him is easier said than done. Not only can Koro-sensei move at speeds of up to Mach 20, but he can also resist almost every earthly weapon. Ironically, he also proves to be one of the best teachers Class 3-E has ever had. Training the class to excel in both their studies as students and skills as assassins, Koro-sensei is confident that his students' ingenuity and indomitable will could return them to the main campus. Through trial and error, Nagisa Shiota, as well as the other students of Class 3-E, must figure out Koro-sensei's weaknesses—and fast, for the very fate of the world depends upon it.

At the renowned Shuchiin Academy, Miyuki Shirogane and Kaguya Shinomiya are the student body's top representatives. Ranked the top student in the nation and respected by peers and mentors alike, Miyuki serves as the student council president. Alongside him, the vice president Kaguya—eldest daughter of the wealthy Shinomiya family—excels in every field imaginable. They are the envy of the entire student body, regarded as the perfect couple. However, despite both having already developed feelings for the other, neither are willing to admit them. The first to confess loses, will be looked down upon, and will be considered the lesser. With their honor and pride at stake, Miyuki and Kaguya are both equally determined to be the one to emerge victorious on the battlefield of love!

Fifteen years after a cataclysmic event known as the Second Impact, the world faces a new threat: monstrous celestial beings called Angels invade Tokyo-3 one by one. Mankind is unable to defend themselves against the Angels despite utilizing their most advanced munitions and military tactics. The only hope for human salvation rests in the hands of NERV, a mysterious organization led by the cold Gendou Ikari. NERV operates giant humanoid robots dubbed Evangelions to combat the Angels with state-of-the-art advanced weaponry and protective barriers known as Absolute Terror Fields. Years after being abandoned by his father, Shinji Ikari, Gendou's 14-year-old son, returns to Tokyo-3. Shinji undergoes a perpetual internal battle against the deeply buried trauma caused by the loss of his mother and the emotional neglect he suffered at the hands of his father. Terrified to open himself up to another, Shinji's life is forever changed upon meeting 29-year-old Misato Katsuragi, a high-ranking NERV officer who shows him a free-spirited maternal kindness he has never experienced. A devastating Angel attack forces Shinji into action as Gendou reveals his true motive for inviting his son back to Tokyo-3: Shinji is the only child capable of efficiently piloting Evangelion Unit-01, a new robot that synchronizes with his biometrics. Despite the brutal psychological trauma brought about by piloting an Evangelion, Shinji defends Tokyo-3 against the angelic threat, oblivious to his father's dark machinations.

Corrupt politicians, frenzied nationalists, and other warmongering forces constantly jeopardize the thin veneer of peace between neighboring countries Ostania and Westalis. In spite of their plots, renowned spy and master of disguise Twilight fulfills dangerous missions one after another in the hope that no child will have to experience the horrors of war. In the bustling Ostanian city of Berlint, Twilight dons the alias of Loid Forger, an esteemed psychiatrist. However, his true intention is to gather intelligence on prominent politician Donovan Desmond, who only appears rarely in public at his sons' school: the prestigious Eden Academy. Enlisting the help of unmarried city hall clerk Yor Briar to act as his wife and adopting the curious six-year-old orphan Anya as his daughter, Loid enacts his master plan. He will enroll Anya in Eden Academy, where Loid hopes she will excel and give him the opportunity to meet Donovan without arousing suspicion. Unfortunately for Loid, even a man of his talents has trouble playing the figure of a loving father and husband. And just like Loid is hiding his true identity, Yor—who is an underground assassin known as Thorn Princess—and Anya—an esper who can read people's minds—have no plans to disclose their own secrets either. Although this picture-perfect family is founded on deception, the Forgers gradually come to understand that the love they share for one another trumps all else.