Masane Amaha and her daughter Rihoko are on the run from a government child welfare agency that wants to take Rihoko away from her mother. They are caught and Rihoko is taken away. Meanwhile, Masane is attacked by an advanced weapon that can disguise itself as a human being. When faced with the danger, a strange light emits from her wrist and she transforms into a powerful being. She destroys the weapon and consequently becomes involved in a power struggle between powerful organizations, with her at the center of their attention. Because she holds the greatest power of them all, the legendary Witchblade. (Source: AniDB)

Born into a loving family, Femicia appears to have a bright future ahead of her. When she finally turns five, the time comes to go to the church to have her skills appraised. However, while she does receive a monster tamer skill, it turns out that Femicia has zero stars for that ability. To make matters worse, society considers those who have zero stars to be harbingers of misfortune; as a result, Femicia is shunned by everyone—including her family. Soon enough, Femicia is chased out of her village and is constantly on the run. Fearing for her life, she decides to masquerade as a boy and change her name to Ivy. With a goal given to her by a fortune teller to reach the royal capital, Ivy meets and successfully tames a slime, starting an unlikely friendship that may provide a means to get the destiny she deserves.

Mitsuha Yamano could not have had it worse. After failing to enter her university of choice and losing her entire family in an accident, she finds herself plummeting off a cliff due to an especially fragile guardrail. Through what seems to be the only bit of the fortune left in her life, Mitsuha's firm unwillingness to die allows her to be transported to another world, where she ends up surviving. In this foreign land, Mitsuha wanders around for days before collapsing from exhaustion and being rescued by a little girl named Colette. Not long after, she finds herself in yet another life-threatening situation, and her indomitable will shines once more, granting her an audience with a divine cosmic being. The entity reveals to Mitsuha that she has acquired not only superhuman regeneration but also the ability to transport between worlds at will. Armed with this new information, Mitsuha brainstorms ways to utilize her newfound power to its full potential. Realizing that she can take goods from Earth and resell them to the other world at a higher price, she resolves to save up eighty thousand gold coins to be able to retire comfortably.

Koguma, a reserved second-year high school student, has nothing—no parents, hobbies, friends, or goals. On her way home one afternoon, she visits a vehicle shop in hopes of acquiring a motor scooter. With only enough money to make ends meet, she is disheartened by the price tags and prepares to turn back. However, as she is about to leave, the shop's owner offers her a pre-owned Honda Super Cub for ten thousand yen. Believing that the motorcycle will help brighten her monotonous world, she accepts the deal. As Koguma journeys through her town on small adventures with her Super Cub, she begins to build irreplaceable friendships and eagerly advances toward her new life.