Mirai Kuriyama is the sole survivor of a clan of Spirit World warriors with the power to employ their blood as weapons. As such, Mirai is tasked with hunting down and killing youmu—creatures said to be the manifestation of negative human emotions. One day, while deep in thought on the school roof, Mirai comes across Akihito Kanbara, a rare half-breed of youmu in human form. In a panicked state, she plunges her blood saber into him only to realize that he's an immortal being. From then on, the two form an impromptu friendship that revolves around Mirai constantly trying to kill Akihito, in an effort to boost her own wavering confidence as a Spirit World warrior. Eventually, Akihito also manages to convince her to join the Literary Club, which houses two other powerful Spirit World warriors, Hiroomi and Mitsuki Nase. As the group's bond strengthens, however, so does the tenacity of the youmu around them. Their misadventures will soon turn into a fight for survival as the inevitable release of the most powerful youmu, Beyond the Boundary, approaches.

The elite members of Shuchiin Academy's student council continue their competitive day-to-day antics. Council president Miyuki Shirogane clashes daily against vice-president Kaguya Shinomiya, each fighting tooth and nail to trick the other into confessing their romantic love. Kaguya struggles within the strict confines of her wealthy, uptight family, rebelling against her cold default demeanor as she warms to Shirogane and the rest of her friends. Meanwhile, council treasurer Yuu Ishigami suffers under the weight of his hopeless crush on Tsubame Koyasu, a popular upperclassman who helps to instill a new confidence in him. Miko Iino, the newest student council member, grows closer to the rule-breaking Ishigami while striving to overcome her own authoritarian moral code. As love further blooms at Shuchiin Academy, the student council officers drag their outsider friends into increasingly comedic conflicts.

In a civilized society of anthropomorphic animals, an uneasy tension exists between carnivores and herbivores. At Cherryton Academy, this mutual distrust peaks after a predation incident results in the death of Tem, an alpaca in the school's drama club. Tem's friend Legoshi, a grey wolf in the stage crew, has been an object of fear and suspicion for his whole life. In the immediate aftermath of the tragedy, he continues to lay low and hide his menacing traits, much to the disapproval of Louis, a red deer and the domineering star actor of the drama club. When Louis sneaks into the auditorium to train Tem's replacement for an upcoming play, he assigns Legoshi to lookout duty. That very night, Legoshi has a fateful encounter with Haru, a white dwarf rabbit scorned by her peers. His growing feelings for Haru, complicated by his predatory instincts, force him to confront his own true nature, the circumstances surrounding the death of his friend, and the undercurrent of violence plaguing the world around him.

Having slept through all four of her alarms, the energetic Narumi Momose finds herself running late for her first day of work at a new office. As she races to catch her train, she makes a promise to herself that none of her coworkers will find out about her dark secret: that she is an otaku and a fujoshi. Her plan goes instantly awry, though, when she runs into Hirotaka Nifuji, an old friend from middle school. Although she tries to keep her secret by inviting him out for drinks after work, her cover is blown when he casually asks her whether or not she will be attending the upcoming Summer Comiket. Luckily for her, the only witnesses—Hanako Koyanagi and Tarou Kabakura—are otaku as well. Later that night, the pair go out for drinks so that they can catch up after all the years apart. After Narumi complains about her previous boyfriend breaking up with her because he refused to date a fujoshi, Hirotaka suggests that she try dating a fellow otaku, specifically himself. He makes a solemn promise to always be there for her, to support her, and to help her farm for rare drops in Monster Hunter. Blown away by the proposal, Narumi agrees immediately. Thus the two otaku start dating, and their adorably awkward romance begins.