During the summer of her freshman year of high school, Yuzu Aihara's mother remarried, forcing her to transfer to a new school. To a fashionable socialite like Yuzu, this inconvenient event is just another opportunity to make new friends, fall in love, and finally experience a first kiss. Unfortunately, Yuzu's dreams and style do not conform with her new ultrastrict, all-girls school, filled with obedient shut-ins and overachieving grade-skippers. Her gaudy appearance manages to grab the attention of Mei Aihara, the beautiful and imposing student council president, who immediately proceeds to sensually caress Yuzu's body in an effort to confiscate her cellphone. Thoroughly exhausted from her first day, Yuzu arrives home and discovers a shocking truth—Mei is actually her new step-sister! Though Yuzu initially tries to be friendly with her, Mei's cold shoulder routine forces Yuzu to begin teasing her. But before Yuzu can finish her sentence, Mei forces her to the ground and kisses her, with Yuzu desperately trying to break free. Once done, Mei storms out of the room, leaving Yuzu to ponder the true nature of her first kiss, and the secrets behind the tortured expression in the eyes of her new sister.

In the town of Kamisu 66, 12-year-old Saki Watanabe has just awakened to her psychic powers and is relieved to rejoin her friends—the mischievous Satoru Asahina, the shy Mamoru Itou, the cheerful Maria Akizuki, and Shun Aonuma, a mysterious boy whom Saki admires—at Sage Academy, a special school for psychics. However, unease looms as Saki begins to question the fate of those unable to awaken to their powers, and the children begin to get involved with secretive matters such as the rumored Tainted Cats said to abduct children. Shinsekai yori tells the unique coming-of-age story of Saki and her friends as they journey to grow into their roles in the supposed utopia. Accepting these roles, however, might not come easy when faced with the dark and shocking truths of society, and the impending havoc born from the new world.

Traveling merchant Kraft Lawrence continues his northward journey with wolf goddess Holo, in search of her lost home of Yoitsu. Lawrence and his sharp-witted partner continue to make some small profits along the way, while slowly uncovering more information about Holo's hometown. However, the road to Yoitsu is a bumpy one filled with many troubles—Lawrence runs into a charming young fellow merchant who has his eyes set on the female wolf companion, and he begins to doubt if Holo will remain by his side; he and the goddess will also have to consider precarious and risky business deals as Lawrence strives to achieve his dream of becoming a shopowner. All the while, with his determination tested at every turn during his journey, Lawrence must question his relationship with Holo, take on business ventures, and ask himself whether it is time for him and Holo to go their separate ways.

Yoshiko Hanabatake is an idiot beyond all belief. Somehow managing to consistently score zeroes on all of her tests and consumed by an absurd obsession with bananas, her senseless acts have caused even her own mother to lose all hope. Only one person is up to the task of keeping her insanity in check: childhood friend Akuru A-kun Akutsu. Though he bemoans the ridiculous behavior he has to endure, the studious but terrifying A-kun is always ready to put an end to any stupidity Yoshiko gets up to, with no qualms about using physical force. Unfortunately, no matter how many times he attempts to knock some sense into her, the girl bounces right back to her usual shenanigans, even dragging in some other eccentrics along for the ride. Try as he might to rein in her nonsense, every moment is unpredictable with Yoshiko and her profound idiocy on the loose.