Known for her semblance to the Sadako character of The Ring series, Sawako Kuronuma is given the nickname Sadako and misunderstood to be frightening and malicious like her fictional counterpart, despite having a timid and sweet nature. Longing to make friends and live a normal life, Sawako is naturally drawn to the cheerful and friendly Shouta Kazehaya, the most popular boy in her class. From their first meeting, Sawako has admired Kazehaya's ability to be the center of attention and aspires to be like him. When Kazehaya organizes a test of courage for the entire class and encourages her to attend, Sawako sees this as an opportunity to get along with her classmates, starting with Ayane Yano and Chizuru Yoshida. Through each new encounter and emotion she experiences, Sawako believes that meeting Kazehaya has changed her for the better. Little does Sawako know, her presence has also changed Kazehaya.

Yoichi Isagi was mere moments away from scoring a goal that would have sent his high school soccer team to the nationals, but a split-second decision to pass the ball to his teammate cost him that reality. Bitter, confused, and disappointed, Isagi wonders if the outcome would have been different had he not made the pass. When the young striker returns home, an invitation from the Japan Football Union awaits him. Through an arbitrary and biased decision-making process, Isagi is one of three hundred U-18 strikers selected for a controversial project named Blue Lock. The project's ultimate goal is to turn one of the selected players into the star striker for the Japanese national team. To find the best participant, each diamond in the rough must compete against others through a series of solo and team competitions to rise to the top. Putting aside his ethical objections to the project, Isagi feels compelled to fight his way to the top, even if it means ruthlessly crushing the dreams of 299 aspiring young strikers.

Keita Amano is a typical high school gamer living out an average student's life. One day, however, he has an unexpected meeting with the cutest girl in school that makes him want to disappear without a trace! This girl, Karen Tendou, is an exemplary student who is proclaimed to be the school's idol. She discovers that Amano is a gamer, and this newfound knowledge incites a passionate desire within her to recruit him into the game club. Upon visiting the club, Amano is forcefully made aware of a side to gaming wildly different than the one he loves so dearly. Tendou's interest in Amano begins shaking up what was once an uneventful life, filling it with spontaneity, awkwardness, and a little bit of mayhem. As a result, every day becomes a comical battle for Amano's sanity as he tries to adapt to these wild, unexpected changes.

Nichijou primarily focuses on the daily antics of a trio of childhood friends—high school girls Mio Naganohara, Yuuko Aioi and Mai Minakami—whose stories soon intertwine with the young genius Hakase Shinonome, her robot caretaker Nano, and their talking cat Sakamoto. With every passing day, the lives of these six, as well as of the many people around them, experience both the calms of normal life and the insanity of the absurd. Walking to school, being bitten by a talking crow, spending time with friends, and watching the principal suplex a deer: they are all in a day's work in the extraordinary everyday lives of those in Nichijou.