In an alternate history, following World War II, civil unrest and terrorism run rampant in a devastated Japan under foreign occupation. During a botched interception of underground munitions being transferred by a terrorist organization, Constable Kazuki Fuse, a soldier in an elite counter-terrorism unit, witnesses the true terror of human nature. He fails to prevent a teenage girl from carrying out a desperate suicide bombing that subsequently causes immense destruction to Tokyo. With mental scars and his competence under question, Fuse is sent back to the military academy for re-evaluation. Unbeknownst to him, he will soon be caught up in a web of government conspiracies that have the power to determine the future of all of Japan. As Fuse treads the fine line between human and beast, he ultimately discovers to which side he truly belongs.

Eight hundred years ago, terrifying demons threatened mankind's existence. On the brink of extinction, humans prayed to their gods, calling out for someone to save them. Emerging from these desperate pleas for salvation, battle deities known as the Idaten were born. Possessing unnatural strength and endurance, the Idaten managed to defeat the demons and an era of unprecedented peace was finally ushered in. Having never encountered demons before, the present generation of Idaten knows nothing of the demon's brutality, but they have instead only lived a peaceful existence. Training under Rin, the only remaining Idaten from 800 years ago, the new Idaten find ways to survive in a time where they have seemingly outlived their usefulness. However, when the tyrannical Zoble Empire resurrects a demon, the misfit crop of gods are called to the battlefield against their natural enemy once more.

On the precipice of a cataclysmic drought, the Star Readers of the Shin Yogo Empire must devise a plan to avoid widespread famine. It is written in ancient myths that the first emperor, along with eight warriors, slew a water demon to avoid a great drought and save the land that was to become Shin Yogo. If a water demon was to appear once more, its death could bring salvation. However, the water demon manifests itself within the body of the emperor's son, Prince Chagum—by the emperor's order, Chagum is to be sacrificed to save the empire. Meanwhile, a mysterious spear-wielding mercenary named Balsa arrives in Shin Yogo on business. After saving Chagum from a thinly veiled assassination attempt, she is tasked by Chagum's mother to protect him from the emperor and his hunters. Bound by a sacred vow she once made, Balsa accepts. Seirei no Moribito follows Balsa as she embarks on her journey to protect Chagum, exploring the beauty of life, nature, family, and the bonds that form between strangers.

Vash the Stampede is a contradiction. He has a notorious reputation as The Humanoid Typhoon, laying anything he comes across to waste on the desolate planet of Gunsmoke. However, Vash is in fact very non-confrontational and kind-hearted, living by a code of pacifism. Twenty years ago, a high-profile bank heist went sour. The ringleader, Gasback Gallon Getaway, swore to get back at his backstabbing crew and the man who stopped him from killing them: Vash the Stampede. In the present day, the traitorous crew has been living the good life as successful entrepreneurs and politicians. Although two decades have passed, Gasback's bitterness has not waned as he aims to take them down one by one, by any means necessary. Just in time to foil Gasback's plot, Vash has arrived in Macca City. Teaming up with the mysterious Amelia Ann McFly, along with the insurance agents Milly Thompson and Meryl Stryfe, Vash is ready to rumble.