Hunters devote themselves to accomplishing hazardous tasks, all from traversing the world's uncharted territories to locating rare items and monsters. Before becoming a Hunter, one must pass the Hunter Examination—a high-risk selection process in which most applicants end up handicapped or worse, deceased. Ambitious participants who challenge the notorious exam carry their own reason. What drives 12-year-old Gon Freecss is finding Ging, his father and a Hunter himself. Believing that he will meet his father by becoming a Hunter, Gon takes the first step to walk the same path. During the Hunter Examination, Gon befriends the medical student Leorio Paladiknight, the vindictive Kurapika, and ex-assassin Killua Zoldyck. While their motives vastly differ from each other, they band together for a common goal and begin to venture into a perilous world.

Eighth-grader Shigeo Mob Kageyama has tapped into his inner wellspring of psychic prowess at a young age. But the power quickly proves to be a liability when he realizes the potential danger in his skills. Choosing to suppress his power, Mob's only present use for his ability is to impress his longtime crush, Tsubomi, who soon grows bored of the same tricks. In order to effectuate control on his skills, Mob enlists himself under the wing of Arataka Reigen, a con artist claiming to be a psychic, who exploits Mob's powers for pocket change. Now, exorcising evil spirits on command has become a part of Mob's daily, monotonous life. However, the psychic energy he exerts is barely the tip of the iceberg; if his vast potential and unrestrained emotions run berserk, a cataclysmic event that would render him completely unrecognizable will be triggered. The progression toward Mob's explosion is rising and attempting to stop it is futile.

After successfully passing his Provisional Hero License exam, Izuku Deku Midoriya seeks out an extracurricular internship with a professional hero agency. At the recommendation of his mentor All Might, Midoriya lands a position under All Might's former sidekick, Sir Nighteye, now a famous hero in his own right. As Midoriya's classmates further their own abilities through various internships, up-and-coming villain Kai Chisaki utilizes his terrifying powers to gather favor in the criminal underworld. Known by the moniker Overhaul, Chisaki's ambitions collide with the League of Villains and its leader, Tomura Shigaraki. Through his work with Sir Nighteye, Midoriya discovers Chisaki's crime syndicate and the villain's hostile relationship with a mysterious young girl named Eri. Fearing for the child's safety, Midoriya and his upperclassman Mirio Toogata must work together to put an end to Chisaki's reign of terror.

Tomoya Okazaki is a delinquent who finds life dull and believes he'll never amount to anything. Along with his friend Youhei Sunohara, he skips school and plans to waste his high school days away. One day while walking to school, Tomoya passes a young girl muttering quietly to herself. Without warning she exclaims Anpan! (a popular Japanese food) which catches Tomoya's attention. He soon discovers the girl's name is Nagisa Furukawa and that she exclaims things she likes in order to motivate herself. Nagisa claims they are now friends, but Tomoya walks away passing the encounter off as nothing. However, Tomoya finds he is noticing Nagisa more and more around school. Eventually he concedes and befriends her. Tomoya learns Nagisa has been held back a year due to a severe illness and that her dream is to revive the school's drama club. Claiming he has nothing better to do, he decides to help her achieve this goal along with the help of four other girls. As Tomoya spends more time with the girls, he learns more about them and their problems. As he attempts to help each girl overcome her respective obstacle, he begins to realize life isn't as dull as he once thought.