After obtaining information about Asirpa from the foreteller Inkarmat, Saichi The Immortal Sugimoto, Genjirou Tanigaki, and Cikapasi join the Seventh Division's Otonoshin Koito and Hajime Tsukishima on a journey to Karafuto. Heading further north into the freezing Russian territory, they collect any clues about Asirpa's whereabouts they can find and rush after her. Meanwhile, Asirpa is unaware of what truly transpired at Abashiri Prison. Deeply disturbed and confused by her father Wilk's past actions, Asirpa follows his old friend Kiroranke to the place where Wilk was born and raised in order to better understand his motives. However, Kiroranke and the master sniper Hyakunosuke Ogata are scheming behind her back. Even if they were to obtain all 24 tattooed skins that form a map to the lost Ainu gold, the various factions searching for it now understand that the map is useless without Asirpa. Realizing the danger she could be in, Sugimoto desperately hopes to reach Asirpa first and protect her from the greedy clutches of those who plan to drag her into their sins.

Touta Konoe is an ordinary boy raised in a small rural town. His mundane life suddenly changes when his mentor, Yukihime, reveals herself to be a vampire; after saving Touta from a mortal wound, she causes him to become immortal as well. Already yearning to explore the world, young Touta finally puts his dream to ascend to the top of Amanomihashira—a tower that leads to outer space—into realization. Along the way, he finds a secret society filled with immortals just like him called UQ Holders. Gaining new comrades and mentorship along the way, Touta embarks on his own unique, magical adventure.

Bestowed with magic from God, witches worked to guide humanity toward progress, garnering adoration and fear alike from humans. However, times have since changed. With the advancement of scientific knowledge, humans now stand on an equal footing with witches. Determined to weave their own destinies and establish supremacy over the world, the mighty Redia Empire has ordered the extermination of all witches, which may bring the era of magic to an end. Fleeing from the decree, the famed witch Chloe and her apprentice, Adonis, seek refuge. Hot on their heels, the Empire captures the duo and mercilessly executes Chloe. Agonized by the brutal murder of his master and the callousness of humans, Adonis vows to avenge Chloe by annihilating humanity with the very magic they intend to destroy.

The Mutou family leads a peaceful life: Kouichirou works at a construction site and his wife Mari is returning from an overseas trip. Their daughter Ayumu has just finished her track practice while their son Gou is playing video games at home. However, life as they know it is flipped upside down when a calamitous earthquake strikes the entire Japanese archipelago—obliterating the face of the country in an instant. With society crumbling around them and their nation gradually sinking into the ocean, the Mutou family must band together to survive the catastrophe. Treading the near-apocalyptic setting, they struggle not only to stay alive, but also to learn the difficulty of coping with loss.