Said to be humanity's natural enemy, formidable dragons that belong to an ancient bloodline roam the world. Only two ways prove effective to kill a dragon: freezing their blood with silverine—an aura that comes from silver weapons—or letting their bodies be incinerated by sunlight. Young hunter prodigy Leonica is accompanied by her close friend Ragna, who appears to lack the skills necessary in their profession. Moreover, many shun Ragna, considering him cursed because dragons always seem to attack him and slaughter his close ones. Nevertheless, Leonica sees potential in Ragna and gladly partners up with him. Likewise, Ragna feels certain that Leonica is immune to his misfortune thanks to her incredible strength. His confidence is shaken, however, when Ragna dreams of Leonica's death, believing this to be a prophecy. As the destined day arrives, he comes face-to-face with his future self, who bestows him enormous power and memories from the future to ensure Leonica's safety. In order to succeed, Ragna must join forces with a mysterious figure known as Crimson and eradicate all dragons for good.

On the planet Noman's Land, reporters Meryl Stryfe and Roberto De Niro traverse the desert in search of the infamous outlaw Vash the Stampede. But the man they find near the desolate town of Jeneora Rock is a far cry from the lethal terrorist they expect. In reality, Vash is a passive and carefree drifter; he is a proponent of peace, beloved by the residents of the town. His inaccurate reputation actually stems from the widespread atrocities committed by his twin brother Knives Millions. Still, Vash is dubbed The Humanoid Typhoon'' due to the tendency for violent chaos to follow in his wake. Chaos soon arrives in the form of bounty hunters seeking the high price on Vash's head, and their violent pursuit poses great danger to the town and its precious power plant. Thanks to his gunslinging prowess, Vash is able to resist most of these nefarious forces. Yet he must soon face off against the ultimate evil: the unstoppable destructive power of his malevolent brother.

Cocona is an average middle schooler living with her grandmother. And she who has yet to decide a goal to strive for, soon met a strange girl named Papika who invites her to an organization called Flip Flap. Dragged along by the energetic stranger, Cocona finds herself in the world of Pure Illusion—a bizarre alternate dimension—helping Papika look for crystal shards. Upon completing their mission, Papika and Cocona are sent to yet another world in Pure Illusion. As a dangerous creature besets them, the girls use their crystals to transform into magical girls: Cocona into Pure Blade, and Papika into Pure Barrier. But as they try to defeat the creature before them, three others with powers from a rival organization enter the fray and slay the creature, taking with them a fragment left behind from its body. Afterward, the girls realize that to stand a chance against their rivals and the creatures in Pure Illusion, they must learn to work together and synchronize their feelings in order to transform more effectively.

In 19th-century France, the wife of vampire noble Jean Duchet Godard is murdered in her own home. With the local human authorities unwilling to properly investigate the case, Godard hires a pair of private detectives known to specialize in the supernatural: Tsugaru Shinuchi, a man with a mysterious birdcage; and his partner, Aya Rindou. This enigmatic duo has come from faraway Japan for one purpose—to track down the man who stole both Aya's body and Tsugaru's humanity.