High school student Wakana Gojou spends his days perfecting the art of making hina dolls, hoping to eventually reach his grandfather's level of expertise. While his fellow teenagers busy themselves with pop culture, Gojou finds bliss in sewing clothes for his dolls. Nonetheless, he goes to great lengths to keep his unique hobby a secret, as he believes that he would be ridiculed were it revealed. Enter Marin Kitagawa, an extraordinarily pretty girl whose confidence and poise are in stark contrast to Gojou's meekness. It would defy common sense for the friendless Gojou to mix with the likes of Kitagawa, who is always surrounded by her peers. However, the unimaginable happens when Kitagawa discovers Gojou's prowess with a sewing machine and brightly confesses to him about her own hobby: cosplay. Because her sewing skills are pitiable, she decides to enlist his help. As Gojou and Kitagawa work together on one cosplay outfit after another, they cannot help but grow close—even though their lives are worlds apart.

To the average person, psychic abilities might seem a blessing; for Kusuo Saiki, however, this could not be further from the truth. Gifted with a wide assortment of supernatural abilities ranging from telepathy to x-ray vision, he finds this so-called blessing to be nothing but a curse. As all the inconveniences his powers cause constantly pile up, all Kusuo aims for is an ordinary, hassle-free life—a life where ignorance is bliss. Unfortunately, the life of a psychic is far from quiet. Though Kusuo tries to stay out of the spotlight by keeping his powers a secret from his classmates, he ends up inadvertently attracting the attention of many odd characters, such as the empty-headed Riki Nendou and the delusional Shun Kaidou. Forced to deal with the craziness of the people around him, Kusuo comes to learn that the ordinary life he has been striving for is a lot more difficult to achieve than expected.

Violent misfortunes frequently occur around 16-year-old Yuuta Okkotsu, a timid victim of high school bullying. Yuuta is saddled with a monstrous curse, a power that dishes out brutal revenge against his bullies. Rika Orimoto, Yuuta's curse, is a shadow from his tragic childhood and a potentially lethal threat to anyone who dares wrong him. Yuuta's unique situation catches the attention of Satoru Gojou, a powerful sorcerer who teaches at Tokyo Prefectural Jujutsu High School. Gojou sees immense potential in Yuuta, and he hopes to help the boy channel his deadly burden into a force for good. Yet Yuuta struggles to find his place among his talented classmates: the selectively mute Toge Inumaki, weapons expert Maki Zenin, and Panda. Yuuta clumsily utilizes Rika on missions with the other first-year students, but the grisly aftermath of Rika's tremendous displays of power draws the interest of the calculating curse user Suguru Getou. As Getou strives to claim Rika's strength and use it to eliminate all non-jujutsu users from the world, Yuuta fights alongside his friends to stop the genocidal plot.

Makoto Naegi, a teenager with no remarkable talent, is surprised to learn that he has been accepted into Hope's Peak Private Academy: an elite school that gathers the best students from various fields. Despite believing his admission was just a fluke, Naegi is delighted to attend an institution known for ensuring success to those who graduate. Determined, he enters the front doors of the prestigious academy. However, after losing consciousness inside, Naegi wakes up in a seemingly abandoned classroom. Failing to comprehend how he got there, Naegi begins to explore, and to his surprise, finds his classmates assembled in the gym. While everyone is trying to figure out what happened, they are confronted by the school principal—Monokuma, a robotic teddy bear. The mysterious toy explains that the freshmen are trapped inside the school with only one means of escape—kill a classmate without being discovered. Tension fills the air as Naegi and his classmates realize that they are faced with two choices: participate in Monokuma's killing game, or reside together in the school for the rest of their lives.