Those who receive the Revelation of Babel must overcome many battles and trials. By grasping the hand of their special partner, these Hand Shakers transport themselves to the realm of Ziggurat, an alternate dimension where time no longer exists. Each pair of Hand Shakers must battle it out for the right to meet with God, who will reward them by granting them a single wish. Tazuna Takatsuki, a high school student with a penchant for fixing things, is one of these Hand Shakers. After receiving a request for repairs from Professor Makihara of a nearby university, Tazuna stumbles upon Koyori Akutagawa, a bedridden girl that reminds him of his deceased sister Musubu. Remembering her dying wish to never let go of her hand, Tazuna grasps Koyori's hand and awakens his power as a Hand Shaker. However, Koyori's life is directly tied to her status as a Hand Shaker, meaning if Tazuna was to ever let go of her hand she would die. With meeting God being their only hope for saving her, the duo must find a way to make their unique powers mesh together, overcome the opposing Hand Shakers, and make their wish come true.

Second-year middle schooler Nao Takanashi loves her older brother Shuusuke to the point where she has developed a brother complex. Wanting her brother to see her as a woman, Nao makes advances toward him on a daily basis, which often results in Shuusuke succumbing to and encouraging more of her teasing. One day, while throwing away porn magazines from her brother's room, Nao finds an album containing his childhood photos—none of which include her. Having discovered the truth behind her family relationships, Nao becomes ever more affectionate toward Shuusuke. However, it does not take long for her dreams of monopolizing her brother to be put in jeopardy.

Rud is a tank of the Hero's Party and is said to have the highest defense ever in history. The party often does labyrinth raids, but to Rud, it means more than just a raid. To cure his beloved sister's illness, he is in search for the wish-granting treasure that might be hidden in those labyrinths. But one day, the arrogant hero kicks him from the party after an unsuccessful raid attempt, blaming it on his skills whose effects he is still unaware of. With nowhere else to go and nothing to do, he decides to return to his hometown, where his sister is waiting. On his way there, he saves a girl who was being attacked by a monster. Unexpectedly, this girl has an extremely rare skill called Appraisal. Thanks to her skill, Rud is able to discover the truth behind his unknown skills, which turn out to be very powerful skills. With a defense of 9999 and powerful skills, thus begins the adventure of the strongest tank, Rud! (Source: Square Enix)

While saving a child from harm, otaku Asahi Ikusaba is transported to another world and believes he has reincarnated with cheat skills similar to those of the characters from his favorite games and novels. Unfortunately, reality strikes when an encounter with a powerful monster shows that he is still nothing more than an average person. In this moment of extreme danger, Asahi instinctively calls out to his overly doting sister, Maya, who appears out of nowhere, possessing the overpowered abilities he thought he had. Maya is ecstatic to see her brother again and resolves to use her newfound powers to protect Asahi no matter what. Together, the close-knit siblings attempt to find a way back home while enjoying their new lives. However, it soon becomes clear that their arrival in this world may have had a purpose. With the Demon King's overwhelmingly powerful army approaching, no one but Maya seems to be able to stand in its way.