On the surface, the thought of Kyouko Hori and Izumi Miyamura getting along would be the last thing in people's minds. After all, Hori has a perfect combination of beauty and brains, while Miyamura appears meek and distant to his fellow classmates. However, a fateful meeting between the two lays both of their hidden selves bare. Even though she is popular at school, Hori has little time to socialize with her friends due to housework. On the other hand, Miyamura lives under the noses of his peers, his body bearing secret tattoos and piercings that make him look like a gentle delinquent. Having opposite personalities yet sharing odd similarities, the two quickly become friends and often spend time together in Hori's home. As they both emerge from their shells, they share with each other a side of themselves concealed from the outside world.

In 1950s Japan, Tatsuo Kusakabe relocates himself and his two daughters, Satsuki and Mei, to the countryside to be closer to their mother, who is hospitalized due to long-term illness. As the girls grow acquainted with rural life, Mei encounters a small, bunny-like creature in the yard one day. Chasing it into the forest, she finds Totoro—a giant, mystical forest spirit whom she soon befriends. Before long, Satsuki too meets Totoro, and the two girls suddenly find their lives filled with magical adventures in nature and fantastical creatures of the woods.

During their decade-long quest to defeat the Demon King, the members of the hero's party—Himmel himself, the priest Heiter, the dwarf warrior Eisen, and the elven mage Frieren—forge bonds through adventures and battles, creating unforgettable precious memories for most of them. However, the time that Frieren spends with her comrades is equivalent to merely a fraction of her life, which has lasted over a thousand years. When the party disbands after their victory, Frieren casually returns to her usual routine of collecting spells across the continent. Due to her different sense of time, she seemingly holds no strong feelings toward the experiences she went through. As the years pass, Frieren gradually realizes how her days in the hero's party truly impacted her. Witnessing the deaths of two of her former companions, Frieren begins to regret having taken their presence for granted; she vows to better understand humans and create real personal connections. Although the story of that once memorable journey has long ended, a new tale is about to begin.

During a summer vacation at her grandfather’s house, six-year-old Hotaru Takegawa gets lost in a forest rumored to be inhabited by spirits. While crying out in desperation, Hotaru is approached by Gin—a mysterious boy wearing a mask—who offers to help her. Overjoyed at the sight of another person, Hotaru runs to Gin with open arms only to be rudely fended off. However, she quickly learns the grave reason behind his behavior: a dreadful curse has been cast upon Gin. Should he ever be touched by a human being, he will disappear forever. Though Gin urges her to never return, Hotaru does the exact opposite, and before too long, the two become close friends despite his delicate situation. Nonetheless, as years pass and their mutual feelings grow stronger, Hotaru and Gin start struggling with the boundaries that destiny has set between them.