During the final years of his life, Hiraku Machio remained confined to a hospital bed with a terminal illness until he finally passed away. Taking pity on the unfair life he lived, a god decides to reincarnate Hiraku in another world where he can live as he pleases. Wanting to try farming in this new life, he is bestowed with an all-in-one Almighty Farming Tool that can transform into any useful implement he wishes. Hiraku is then transported to a forest seemingly far from civilization. Here, he plans to build and farm everything from scratch—gradually developing the lifeless area into a thriving new society.

Takashi Natsume, the timid youkai expert and master of the Book of Friends, continues his journey towards self-understanding and acceptance with the help of friends both new and old. His most important ally is still his gluttonous and sake-loving bodyguard, the arrogant but fiercely protective wolf spirit Madara—or Nyanko-sensei, as Madara is called when in his usual disguise of an unassuming, pudgy cat. Natsume, while briefly separated from Nyanko-sensei, is ambushed and kidnapped by a strange group of masked, monkey-like youkai, who have spirited him away to their forest as they desperately search for the Book of Friends. Realizing that his servant has been taken out from right under his nose, Nyanko-sensei enlists the help of Natsume's youkai friends and mounts a rescue operation. However, the forest of the monkey spirits holds many dangerous enemies, including the Matoba Clan, Natsume's old nemesis. Stretching from the formidable hideout of the Matoba to Natsume's own childhood home, Natsume Yuujinchou Shi is a sweeping but familiar return to a world of danger and friendship, where Natsume will finally confront the demons of his own past.

In the witches' tradition, when a practitioner turns 15, they must become independent and leave their home to study witchcraft. Makoto Kowata is one such apprentice witch who leaves her parents' home in Yokohama in pursuit of knowledge and training. Along with her companion Chito, a black cat familiar, they embark on a journey to Aomori, a region favored by witches due to its abundance of nature and affinity with magic. They begin their new life by living with Makoto's second cousins, Kei Kuramoto and his little sister Chinatsu. While Makoto may seem to be attending high school like any other teenager, her whimsical and eccentric involvement with witchcraft sets her apart from others her age. From her encounter with an anthropomorphic dog fortune teller to the peculiar magic training she receives from her older sister Akane, Makoto's peaceful everyday life is filled with the idiosyncrasies of witchcraft that she shares with her friends and family.

Eighteen-year-old Dale Reki is a skilled, kind, and respected traveler, acknowledged as one of the leading adventurers in the city of Kreuz. One day while on the hunt for magical beasts, he comes across a sweet devil girl named Latina. She is alone, dressed in rags, and bears the devils' symbol of a criminal: a broken horn. Concerned for her wellbeing, Dale decides to ensure Latina's safety by bringing her to his home, eventually leading to him adopting her. Latina is sweet, innocent and compassionate, charming Dale beyond his expectations. He begins to enjoy the life of parenthood— experiencing the trials that come with raising a child and coping with the heartache he feels whenever his busy lifestyle as an adventurer parts him from her. Although work and life as a new parent become reassuring constants for Dale, the mysteries surrounding the girl remain. Why was Latina alone in the forest, and why does she harbor the symbol of a criminal? At the same time, Latina also begins to learn about the world and herself as she adjusts to her new life with Dale.