A believing heart is your magic!—these were the words that Atsuko Akko Kagari's idol, the renowned witch Shiny Chariot, said to her during a magic performance years ago. Since then, Akko has lived by these words and aspired to be a witch just like Shiny Chariot, one that can make people smile. Hence, even her non-magical background does not stop her from enrolling in Luna Nova Magical Academy. However, when an excited Akko finally sets off to her new school, the trip there is anything but smooth. After her perilous journey, she befriends the shy Lotte Yansson and the sarcastic Sucy Manbavaran. To her utmost delight, she also discovers Chariot's wand, the Shiny Rod, which she takes as her own. Unfortunately, her time at Luna Nova will prove to be more challenging than Akko could ever believe. She absolutely refuses to stay inferior to the rest of her peers, especially to her self-proclaimed rival, the beautiful and gifted Diana Cavendish, so she relies on her determination to compensate for her reckless behavior and ineptitude in magic. In a time when wizardry is on the decline, Little Witch Academia follows the magical escapades of Akko and her friends as they learn the true meaning of being a witch.

Upon his run-in with a Vouivre—a monster known to be very dangerous—Hestia Familia's captain Bell Cranel is struck with incomprehension. Despite its preceding reputation, the supposed bloodthirsty creature happens to be crying and flees from a group of adventurers. The monster, taking the form of a terrified little girl, prompts Bell to swiftly decide to hide her. Unbeknownst to him, this act of kindness will cause massive repercussions that will soon echo throughout the entire city of Orario.

Individuals who can materialize weapons from their soul are called Blazers, and they attend Kouryou Academy High School in order to harness their abilities. Each student is required to partner with another, in the hopes that one day, the pair can attain the power of Absolute Duo. Tooru Kokonoe hopes to attend this academy in order to gain power after his sister and friends were slain by a mysterious man. However, at the opening ceremony, he is forced to duel against the person sitting next to him, with the loser being expelled. As Tooru prepares to give the match his all, it is not a weapon that manifests from his soul, but a shield, an irregularity which catches the attention of a foreign student named Julie Sigtuna.

Izayoi Sakamaki, Asuka Kudou, and You Kasukabe are extraordinary teenagers who are blessed with psychic powers but completely fed up with their disproportionately mundane lives—until, unexpectedly, each of them receives a strange envelope containing an invitation to a mysterious place known as Little Garden. Inexplicably dropped into a vast new world, the trio is greeted by Kurousagi, who explains that they have been given a once-in-a-lifetime chance to participate in special high-stakes games using their abilities. In order to take part, however, they must first join a community. Learning that Kurousagi's community No Names has lost its official status and bountiful land due to their defeat at the hands of a demon lord, the group sets off to help reclaim their new home's dignity, eager to protect its residents and explore the excitement that Little Garden has to offer.