Angelise Ikaruga Misurugi is the first princess of the noble Misurugi Empire. The kingdom has seen great power and prosperity due to the advancement of the revolutionary technology known as Mana, an abstract bending of light that has reduced the world's problems of war and pollution to a timeless peace. However, not all are blessed with the ability to wield Mana. Those who cannot are labeled Norma, outcasts of society who are considered a threat to civilization and live under constant persecution, and Angelise herself is one of many who want the Norma exterminated. But as Angelise's sixteenth birthday commences, it is discovered in a shocking revelation that she is actually a Norma. Chaos ensues, the public is outraged, and the once adored princess is exiled to Arzenal: a remote military base where Normas are forced into conscription. Now, the former royal must adapt to a harsh and vastly different lifestyle; piloting mechanical robots known as Paramail to fend off large, devastating beasts referred to as DRAGONs. However, a sinister truth about these savage creatures threatens to change everything.

Touta Konoe is an ordinary boy raised in a small rural town. His mundane life suddenly changes when his mentor, Yukihime, reveals herself to be a vampire; after saving Touta from a mortal wound, she causes him to become immortal as well. Already yearning to explore the world, young Touta finally puts his dream to ascend to the top of Amanomihashira—a tower that leads to outer space—into realization. Along the way, he finds a secret society filled with immortals just like him called UQ Holders. Gaining new comrades and mentorship along the way, Touta embarks on his own unique, magical adventure.

At Kaimei High School there is a special club dedicated to helping others known as the SKET Brigade. The brains of the group is Kazuyoshi Switch Usui, a tech-savvy otaku who speaks through speech synthesis software, while the brawn is provided by Hime Himeko Onizuka, the hockey stick-wielding girl once known as Onihime. And last but not least, their leader is Yuusuke Bossun Fujisaki, whose latent ability is evoked by his goggles, allowing him to summon the awesome power of extraordinary concentration. However, most of the school only know them as the club that handles odd jobs. Many of their days are spent in the clubroom slacking off, but when there is something to be done, they give their all to help others—usually in sincere, but unintentionally hilarious, ways. The SKET Brigade do all they can to provide support, kindness, encouragement, and troubleshooting to any students crazy enough to ask for their services.

Shogi, a Japanese game similar to chess, is one of the most popular board games in the country, played by everyone from children to the elderly. Some players are talented enough to take the game to a professional level. The title of Ryuuou, meaning the dragon king, is only awarded to the person who reaches the pinnacle of competitive shogi. Yaichi Kuzuryuu has just become the youngest Ryuuou after winning the grand championship. However, the shogi community is unwelcoming to his victory, some even calling him the worst Ryuuou in history. Moreover, he forgets about the agreement he made with Ai Hinatsuru, a little girl he promised to coach if he won. After she shows up at his doorstep, he reluctantly agrees to uphold his promise and makes Ai his disciple. Together, they aim to improve and exceed the limits of their shogi prowess: Ai, to unlock her hidden talents; Yaichi, to prove to the world that he deserves his accomplishments.