Setsuna Mudo is a 16-year-old high school student just trying to get by without running afoul of his bullying seniors. It doesn't help that he's in love with his younger sister, Sara, who only sees him once a month. But there's more to his life than just keeping his head down. Setsuna is ambushed by mysterious beings, angels, and demons, all professing to know his true destiny. The angels say he is the reincarnation of their leader Alexiel, while the demons claim he led them to war against God himself. As Setsuna struggles with his identity in such strange times, the eternal conflict between Heaven and Hell threatens to reignite. Will he be prepared when it does?

Murasame Sumika is popular in the high school for her excellence in the marks and sports. However, she has a secret: she is in love with her classmate Kazama Ushio. Ushio also has a liking to the love between girls, but she hasn't noticed Sumika's feelings and has always been refused by other girls.

When mundane office worker Kiyoshi Adachi turns 30 years old, he discovers that he has gained the ability to read minds due simply to remaining a virgin for his entire life. The caveat, however, is that he must make physical contact with a person to know what they are thinking about. Adachi believes there is no real use for this power until he accidentally hears the thoughts of his coworker, Yuuichi Kurosawa. Charismatic and dependable, Kurosawa is the star of Adachi's team at work, earning praise and admiration from everyone at the office. But deep within, Kurosawa harbors an intense one-sided crush for the gloomy Adachi—a fact that Adachi only learns because of his ability, and knowledge he tries to respectfully disregard. As Kurosawa treats Adachi with kindness and affection he has never experienced before, Adachi finds it increasingly difficult to ignore his coworker's genuine advances.

Saki Uno is an average 15-year-old girl with a side hustle as a member of the exceptionally unpopular idol duo Magical Twins. Despite this, she absolutely loves the time she spends with her best friend Sakuyo Mikage as she strives to become closer with her childhood crush, Sakuyo's brother Mohiro. Her peaceful life, however, unravels when she finds a yakuza-looking thug trying to enter her house. Forced to invite him inside, Saki learns that her mother used to be a demon fighting Magical Girl, and that her brutish guest is actually a mascot named Kokoro-chan looking to recruit a replacement. Dumbfounded and skeptical, Saki is hesitant accept the request until Kokoro-chan reveals that Mohiro is a target of some cute, squirrel-tailed demons. Rushing to his side, Saki's overwhelming desire to save Mohiro activates her Love Power, and a daring confession awakens her as a Magical Girl. However, because her body is not suitable for combat, Saki's transformation turns her into a muscle-bound man clad in a pretty dress. Now, as a fully-fledged Magical Girl, Saki must team up with Sakuyo to protect the love of her life from the fluffy, demonic menaces that run rampant in her world.