After a decade spent fighting monsters in the Shadow Labyrinth—a growing dark cloud of magic that threatens to engulf the world and destroy all life—mage Desir Herrman and his five companions finally face their last foe: the dragon of destruction Boromir Napolitan. Although the group of heroes manages to slay this formidable opponent, the tremendous amount of mana stored within the dragon's body is released in an unstoppable explosion that annihilates the rest of the world. However, instead of dying, Desir is sent back 10 years into the past with complete memories of events to come. He enrolls at Hebrion Academy, determined to put an end to the classist prejudice plaguing the magical world that will ultimately lead to the demise of humanity. Unfortunately, his struggle begins early on during the entrance exams; although he is ranked first of his group, Desir is assigned to the Beta Class, the default class for commoners. Now, Desir's next objective is to rally someone to his cause that he could not save in his previous life: the wind mage Romantica Eru. Then, Desir will have to show his worth to the Alpha Class with his newly formed party if he wants to ultimately save as many lives as possible.

In the year 5053, French aristocrats Viscount Albert de Morcerf and Baron Franz d'Epinay attend the festival of Carnival on the moon city of Luna. While Franz is just looking to have fun, Albert is seeking something more to fill his life—but he finds more than he bargained for in The Count of Monte Cristo, a mysterious and charming self-made nobleman who meets his gaze during an opera performance. Through a few twists and turns, Albert befriends the Count and introduces him into French society. The Count, however, has more on his mind than just friendship; he plots to finally unleash his vengeance on those who wronged him years earlier. Gankutsuou follows Albert and the Count's intertwined destinies and the ultimate price paid for enacting revenge.

Self-professed home security guard Mahiro Oyama has not left his home in years, secluding himself in his room playing erotic visual novels. This depraved lifestyle causes his prodigious sister, Mihari, to worry about his well-being. In hopes of solving this problem, she devises a plan to rehabilitate him back to normalcy. The first part of Mihari's plan is to concoct a medicine that changes her brother's biological constitution into a bona fide female, much to Mahiro's vehement dismay. Stuck in this predicament, Mahiro has no choice but to live out his life as a cute girl until the effect wears off—if it ever does.

Some time ago, the influential and powerful Toue Inc. bought the island of Midorijima, Japan, with the plans of building Platinum Jail—a luxurious utopian facility. Those who are lucky enough to call it home are the wealthiest citizens in the world. The original residents of the island, however, were forced to relocate to the Old Residential District; and after the completion of Platinum Jail, they were completely abandoned. Rib and Rhyme are the most common games played on the island. Rib is an old school game in which gangs engage in turf wars against each other, while Rhyme is a technologically advanced game wherein participants fight in a virtual reality. To be able to play Rhyme, you must have an All-Mate (an AI that typically looks like a pet), and the match must be mediated by an Usui. Aoba Seragaki has no interest in playing either game; he prefers to live a peaceful life with his grandmother and All-Mate, Ren. However, after getting forcefully dragged into a dangerous Rhyme match and hearing rumors about disappearing Rib players, all of Aoba's hopes of living a normal life are completely abolished.