The world as we know it is actually just half the story, as Takeshi Nanase finds out abruptly one summer morning. On his way to kendo practice, Takeshi comes across an unconscious girl in a uniform he doesn't recognize. Takeshi does the decent thing and saves her, and in return the girl wakes up and accidentally turns him into a magic-user. As Takeshi finds out, there is the world he lives in and the world of magic users. Most magic users just want to peacefully coexist with non-magicians, but there are some with bigger ambitions. Mui Aiba is a magician enrolled in the Subaru Magic Academy, where magic users can learn to control and channel their powers and how to live in peace with regular humans. After his fateful encounter with Mui, Takeshi and his newly magician friends Kurumi Isoshima and Kazumi Ida decide to enroll in the Magic Academy as well. All three friends have different reasons for fighting on, whether they're fighting to escape the past or catch up to the future. They wield different kinds of powers, which they must learn to harness in order to fight off the Ghost Trailers, a group of magicians who are willing to use violence to assert their superiority over humans. Pursued by the Ghost Trailers, Takeshi and his friends must train to become stronger, face the leader of the Trailers, and prevent the beginning of the Second Great Magic War.

Despite standing at the zenith as the strongest exorcist, Haruyoshi Kuga sought even greater power, which led to his demise at the hands of those who envied his might. As he draws his last breath, he casts a spell that allows him to reincarnate and swears to become more cunning, hoping that all his efforts will prove useful in his next life. Haruyoshi is soon reborn in another world as Seika Lamprogue, an illegitimate son of a noble family that prides itself on magic. However, his new family largely ignores him due to his lineage and magic deficiency. Nevertheless, the unbothered Seika leverages the knowledge from his previous life to make numerous valuable allies. As he begins to explore the true limits of his abilities, Seika must also be wary of the consequences that tarnished his past and avoid repeating the same mistakes.

Fate Graphite lives miserably as a gatekeeper in a world where skills given at birth determine an individual's entire life. Afflicted by the seemingly harmful skill Gluttony, which makes him perpetually hungry, he is abused by the holy knights—the supposed protectors of the populace—who view him as a dreg on society due to his skill. However, Fate's destiny takes a dramatic turn after he kills an escaping injured thief. To his surprise, Gluttony activates, enhancing his stats and granting him new skills. Following this epiphanic event, Fate receives a job offer from Roxy Hart, the only benevolent holy knight in the city, which he happily accepts. Eager to further explore Gluttony's true potential, he partners with a mysterious talking sword named Greed, who warns him that Gluttony is a taboo skill that breaks the logic of the world. Now forced to live a double life, Fate must slay monsters at night to satisfy his awakened appetite for souls, lest he go berserk and lose all chances at finding happiness.

World-class medical researcher Kanji Yakutani lost his little sister to a tumor years ago due to ineffective treatment. To honor her legacy, he has dedicated his research to developing new medications for such conditions. But as fate would have it, he overworks himself and passes away at the age of 31, only to be given a second chance at life in another world. When he wakes up, Kanji finds himself in the body of a 10-year-old boy named Falma de Médicis, the son of an esteemed family of medical practitioners in the Sain Fleuve Empire. Bearing the mark of a deity's divine blessing, Falma is capable of performing a unique divine art, allowing him to create and reduce any substance with the knowledge of its chemical properties. After reading through some pharmacology books, Falma realizes that this world is operating on similar medical practices as in ancient times. He also learns that medicine is an exclusive privilege to the nobility, depriving commoners of proper medical care. Using the knowledge from his past life and the divine abilities granted to him, Falma resolves to make medicine available to those who need it—irrespective of class.