Maomao, an apothecary's daughter, has been plucked from her peaceful life and sold to the lowest echelons of the imperial court. Now merely a maid, Maomao settles into her new mundane life and hides her extensive knowledge of medicine in order to avoid any unwanted attention. Not long after Maomao's arrival, the emperor's infant children inexplicably begin to experience grave symptoms—almost as if a curse has been cast. The curious Maomao easily solves the mystery and, to remain out of the limelight, attempts to leave an anonymous tip. Unfortunately, the dashing and perceptive eunuch Jinshi sees through it and manages to single her out. In recognition of her talent, Maomao is promoted to lady-in-waiting for the emperor's favorite concubine, Gyokuyou. As Maomao continues to remedy the numerous ailments afflicting the imperial court, her pharmaceutical expertise quickly proves indispensable.

During recess, Olivia, a foreign transfer student who doesn't know English, plays a game of look-the-other-way with Hanako Honda, a loud-mouthed airhead. Their rowdy behavior spurs the ire of Kasumi Nomura, a deadpan loner constantly teased by her older sister for her tendency to lose games. Not willing to compete, Kasumi declines Olivia's offer to join the fun, but eventually gets involved anyway and dispenses her own brand of mischief. Soon, a strange friendship blossoms between the peculiar trio, and they decide to form the Pastime Club, where they are free to resume their daily hijinks. Whether it be failing to learn English, trying desperately to become popular, or getting caught by teachers at the wrong time, school life will never be boring when the girls of Asobi Asobase are up to their hilarious antics.

Usagi Tsukino is an average student and crybaby klutz who constantly scores low on her tests. Unexpectedly, her humdrum life is turned upside down when she saves a cat with a crescent moon on its head from danger. The cat, named Luna, later reveals that their meeting was not an accident: Usagi is destined to become Sailor Moon, a planetary guardian with the power to protect the Earth. Given a special brooch that allows her to transform, she must use her new powers to save the city from evil energy-stealing monsters sent by the malevolent Queen Beryl of the Dark Kingdom. But getting accustomed to her powers and fighting villains are not the only things she has to worry about. She must find the lost princess of the Moon Kingdom, the other Sailor Guardians, and the Legendary Silver Crystal in order to save the planet from destruction.

Misery seems everlasting in Miyo Saimori's life. Born from an arranged marriage, she was quickly discarded after her mother's tragic death. Her father remarried, and her younger half-sister Kaya received all the affection, while Miyo was degraded to a lowly servant. Lacking the strength to fight against her family's abuse, Miyo loses hope that her luck will ever turn. Unexpectedly, Miyo's father summons her to deliver surprising news: she is to marry Kiyoka Kudou, the head of the distinguished Kudou family. Despite his noble background, Kiyoka is known to be a callous man who has thus far dismissed all of his former fiancées. Upon arriving at the Kudou household, Miyo expects coarse treatment and to be tossed aside. However, contrary to her assumptions, Kiyoka shows her the kindness and love that she has desperately needed. Marrying Kiyoka may be Miyo's one chance to break free from her neglectful family and embrace a life of happiness.