Continuing his masquerade as the deranged lunatic from the Lanling Jin Clan, Wei Wuxian resides in the Cloud Recesses while his former cultivation classmate, Lan Wangji, searches for answers about the demonic severed arm they have in custody. With an overwhelming dark energy emanating from the arm, the two are forced to work together in order to keep it contained. However, the demonic arm is not the only dark force lurking in the region, and as spiritual tensions rise in the mountains of the Gusu Lan Clan, it is up to the two of them to try and restore the natural order. The story of Wei Wuxian's fall from grace continues as more light is shed on his descent into the path of demonic cultivation. The demonic arm only further strains his mischievous spirit. This is the time for him to prove that he has truly broken free from the forbidden path and is not the maniacal sorcerer that everyone remembers him to be.

The world of Auldrant is bound by the Score, a series of prophecies from centuries past that dictate the world's future. It is considered an absolute fate that everyone lives by—even people whose actions lead to bloodshed and tears. Using magical abilities known as the Fonic Arts, a war between the nation of Kimlasca-Lanvaldear and the Malkuth Empire is waged in hopes of bringing the Score's foreseen utopia to life. Tales of the Abyss follows Luke von Fabre, who spends his days locked away in his manor after being kidnapped and losing memories as a child. One day, while honing his swordsmanship, a woman named Tear attempts to assassinate his master. Luke defends him, but the clash results in the two being teleported to a distant land. Luke and Tear’s journey back quickly escalates into a quest that will either free the world from the Score's chains or destroy it completely.

In the late 19th century, as the cruel times of the Bakumatsu period came to a close, a new Meiji era marked the age of restoration for Japan. With the war over, its infamous hero Hitokiri Battousai disappeared into thin air, leaving only his legend behind. Years later, a seemingly plain wanderer named Kenshin Himura encounters Kaoru Kamiya, the owner of a struggling local dojo in Tokyo. Kaoru pursues a self-proclaimed Battousai who roams the streets, indiscriminately killing citizens and police officers. Furthermore, the warrior professes to use the Kamiya Kasshin-ryu—a sword style developed by Kaoru's father deeply rooted in the essence of life, not death. Kenshin decides to help Kaoru take down the impostor and restore her father's dojo. Unbeknownst to all, Kenshin is none other than the real warrior whose name still terrifies the people. Although Kaoru eventually learns the truth, his oath to atone for his murderous history by bloodlessly protecting the weak moves her, and she welcomes Kenshin to stay at her dojo. However, Kenshin's ideals are soon challenged by ghosts of the past and enemies of the present.

Hourai is a mysterious island that appears for a limited period once every 50 years. Some say that the isle holds the secret of eternal youth; others believe that it brings disaster to their land. When Inuyasha's group saves a half-demon child from being hunted by a monstrous creature, they learn that her name is Ai and that she fled from Hourai. Surprisingly, the girl is an acquaintance of Inuyasha and begs him to rescue her friends, who are being held prisoner by vicious demons calling themselves the Four War Gods—an enemy Inuyasha remembers well. Upon reaching Hourai, Ai's guests are horrified to discover that only a handful of orphans still inhabit the island and are destined to become sacrifices to increase the Four War Gods' powers. Furthermore, the victims bear their oppressors' enchanted mark, which prevents them from escaping. Defeating the four demons remains Inuyasha's most viable option, but their superiority in strength will require daring initiatives achievable only by the group's combined teamwork.