Holo is a powerful wolf deity who is revered in the small town of Pasloe for blessing the annual harvest. Yet as years go by and the villagers become more self-sufficient, Holo has been reduced to a mere folktale. When a traveling merchant named Kraft Lawrence stops at the settlement, Holo offers to become his business partner if he takes her to her northern home of Yoitsu. The savvy trader recognizes Holo's unusual ability to evaluate a person's character and accepts her proposition. Now in the possession of both sharp bargaining skills and a charismatic negotiator, Lawrence inches closer to his goal of opening his own shop. However, as Lawrence travels the countryside with Holo in search of economic opportunities, he begins to realize that his aspirations are slowly morphing into something unexpected.

Keiichi Maebara has just moved to the quiet little village of Hinamizawa in the summer of 1983, and quickly becomes inseparable friends with schoolmates Rena Ryuuguu, Mion Sonozaki, Satoko Houjou, and Rika Furude. However, darkness lurks underneath the seemingly idyllic life they lead. As the village prepares for its annual festival, Keiichi learns about the local legends surrounding it. To his horror, he discovers that there have been several murders and disappearances in the village in the recent years, and that they all seem to be connected to the festival and the village's patron god, Oyashiro. Keiichi tries to ask his new friends about these incidents, but they are suspiciously silent and refuse to give him the answers he needs. As more and more bizarre events occur, he wonders just what else his friends might be keeping from him, and if he can even trust them at all. When madness and paranoia begin taking root in Keiichi's heart, he will stumble straight into the mysteries at work in Higurashi no Naku Koro ni, a story that is told across multiple arcs.

A goldfish sneaks away from home and floats off on the back of a jellyfish. After getting stuck in a glass jar, she drifts to the shore where she is freed by Sousuke, a five-year-old boy who lives with his mother Lisa in a house by the sea while his father Koichi works on a fishing boat. After healing a cut on Sousuke's finger by licking it, the goldfish is named Ponyo by her new friend. Unknown to Sousuke, Ponyo already has a name and a family. Her father Fujimoto, a sorcerer who forsook his humanity to live underwater, searches frantically for his daughter Brunhilde. When found and captured, Ponyo rejects her birth name and declares that she wants to become a human. Using the power received from Sousuke's blood, she grows arms and legs and escapes to the surface once more. But the magic released into the ocean causes an imbalance in nature, causing the Moon to start falling out of orbit and the tides to grow dangerously stronger. Reunited with Ponyo, Sousuke must pass an ancient test to restore order in the world and let his companion live on as a human.

Kagome Higurashi's 15th birthday takes a sudden turn when she is forcefully pulled by a demon into the old well of her family's shrine. Brought to the past, when demons were a common sight in feudal Japan, Kagome finds herself persistently hunted by these vile creatures, all yearning for an item she unknowingly carries: the Shikon Jewel, a small sphere holding extraordinary power. Amid such a predicament, Kagome encounters a half-demon boy named Inuyasha who mistakes her for Kikyou, a shrine maiden he seems to resent. Because of her resemblance to Kikyou, Inuyasha takes a violent dislike to Kagome. However, after realizing the dire circumstances they are both in, he sets aside his hostility and lends her a hand. Unfortunately, during a fight for the Shikon Jewel, the miraculous object ends up shattered into pieces and scattered across the land. Fearing the disastrous consequences of this accident, Kagome and Inuyasha set out on a challenging quest to recover the shards before they fall into the wrong hands.