The duke, full of love and kindness, treads carefully around every living being, be it a tender flower or his seductive maid, Alice Lendrott. Were it not for the devotion Alice shows him and the fondness that grows ever stronger between them, the duke would have barely paid heed to his mother's demand: to either lift the dreadful curse placed upon him or lose his family inheritance. Although the duke has no greed for riches, he yearns to be rid of his frightful powers—which cause all he touches to die—for the sake of those closest to him. As the duke, Alice, and their friends enjoy spirited days filled with the ridiculous affairs of the supernatural, the spring deadline looms heavily over them. Nonetheless, the duke refuses to take any shortcuts in this endeavor if it means betraying the trust of his cherished friends.

Chika Homura begins her high school career with a goal: to develop a cute girl persona. After quitting the volleyball team despite her all-star status, Chika decides to join her school's underrated Wind Instrument Club and play the flute, believing it to be the most delicate and feminine instrument. For the first time in nine years, Chika reunites with her childhood friend and total opposite, Haruta Kamijou. Unfortunately for Chika, Haruta is not fooled by her efforts to become more endearing. But this does not deter Chika, and she develops a crush on the band instructor, Shinjirou Kusakabe—but so does Haruta! However, Chika's high school life just won't go according to plan, as mysteries begin appearing around her and her friends. The club members must work together to solve the mysteries plaguing the school, all while trying to find more members to compete in musical competitions.

As preparations begin for Seishou Music Academy's yearly Seishou Festival, the girls of the 99th class are gearing up to perform their very own rendition of Starlight, the tragic tale of two goddesses drawn together by the glow of the heavens but destined to be pulled apart, never to meet again. Created to foster the next generation of theatrical talent, this girls' only school works to improve the singing, acting, and dancing skills of its students. One student is 16-year-old Karen Aijou, an easygoing girl who has dreamed of performing on stage since she was a child. Her love for theater is further invigorated when her childhood friend Hikari Kagura transfers to Seishou Academy. Through her old friend, Karen stumbles upon a secret elevator leading to a massive theater underneath the school. Hosted by a talking giraffe, this arena serves as a battleground where her classmates participate in duels to determine who among them deserves the title of Top Star, earning them the right to play one of the lead roles in Starlight. Emboldened by the promise she made with Hikari to someday be stars together, Karen enters these mysterious battles in the hopes of making their dream a reality.

After an interplanetary war at the beginning of the 21st century, planet Earth has been left in ruins, with much of its ecosystem completely destroyed. Because it was no longer possible to live a normal life on this planet, the inhabitants are forced to move on to other planets where life will, hopefully, be more comfortable. The Deep Galactic Trade Organization, a totalitarian government that affects many of the newly inhabited planets, has somehow come to the conclusion that music is a source of evil, and that it must be banned and destroyed for good. The talent group AKB0048 is soon formed, based on the original AKB48 members that once lived on Earth. Even though their music is now considered universally illegal, they make it their mission to bring their music back to life by travelling from one planet to another and holding as many concerts as they possibly can. They must undergo a whole new set of training methods in order to become the best that they can possibly be, while also avoiding the constant danger of being arrested because of their music. Join interplanetary popstars AKB0048 as they try to save the world－with music!