At Suimei High, the Sakura-sou dormitory is infamous for housing the school's most notorious delinquents. Thus, when the relatively tame Sorata Kanda is transferred to the dorm, escaping this insane asylum becomes his foremost goal. Trapped there for the time being, he must learn how to deal with his fellow residents, including bubbly animator Misaki Kamiigusa, charming playboy writer Jin Mitaka, and the ever-reclusive Ryuunosuke Akasaka. Surrounded by weirdness, Sorata frequently finds respite in his interactions with his one normal friend, aspiring voice actress Nanami Aoyama. When Mashiro Shiina—a new foreign exchange student—joins the dormitory, Sorata is instantly enraptured by her beauty. Underneath her otherworldly appearance, Mashiro is an autistic savant, capable of world-renowned brilliance in her art, yet unable to perform simple daily tasks. After Sorata ends up in charge of taking care of Mashiro, the two inevitably grow closer, with Sorata's initial desire to escape the dormitory becoming a forgotten goal. Despite their eccentricities, every resident is incredible in their own field, leaving Sorata to contend with his own lack of any particular skill. With brilliance all around him, he thus strives to become an equal to their talent. Revolving around the hardships and joys of its colorful cast, Sakura-sou no Pet na Kanojo is a heartwarming coming-of-age tale of friendship, love, ambition, and heartbreak—through the lens of an ordinary person surrounded by the extraordinary.

The fierce battle between Meliodas, the captain of the Seven Deadly Sins, and the Great Holy Knight Hendrickson has devastating consequences. Armed with the fragments necessary for the revival of the Demon Clan, Hendrickson breaks the seal, allowing the Commandments to escape, all of whom are mighty warriors working directly under the Demon King himself. Through a mysterious connection, Meliodas instantly identifies them; likewise, the 10 Commandments, too, seem to sense his presence. As the demons leave a path of destruction in their wake, the Seven Deadly Sins must find a way to stop them before the Demon Clan drowns Britannia in blood and terror.

Devils cannot take form without a living host. However, if the will of an individual is strong enough, they can overcome the demon and make its power their own, becoming a Devilman. Weak and unassuming, Akira Fudou has always had a bleeding heart. So when his childhood friend Ryou Asuka asks for his help in uncovering devils, Akira accepts without hesitation. However, to Akira's surprise, the place they go to is Sabbath: an immoral party of debauchery and degeneracy. Amidst bloodshed and death, demons possess the partiers, turning their bodies into grotesque monsters, and begin wreaking havoc. In a reckless attempt to save his best friend, Akira unwittingly merges with the devil Amon and becomes a Devilman, gaining the power to defeat the remaining demons. Though it grants him great power, this new partnership awakens an insatiable and primeval part of Akira. Having the body of a devil but the same crybaby heart, Akira works alongside Ryou, destroying those that harm humanity and his loved ones.

High school student Wakana Gojou spends his days perfecting the art of making hina dolls, hoping to eventually reach his grandfather's level of expertise. While his fellow teenagers busy themselves with pop culture, Gojou finds bliss in sewing clothes for his dolls. Nonetheless, he goes to great lengths to keep his unique hobby a secret, as he believes that he would be ridiculed were it revealed. Enter Marin Kitagawa, an extraordinarily pretty girl whose confidence and poise are in stark contrast to Gojou's meekness. It would defy common sense for the friendless Gojou to mix with the likes of Kitagawa, who is always surrounded by her peers. However, the unimaginable happens when Kitagawa discovers Gojou's prowess with a sewing machine and brightly confesses to him about her own hobby: cosplay. Because her sewing skills are pitiable, she decides to enlist his help. As Gojou and Kitagawa work together on one cosplay outfit after another, they cannot help but grow close—even though their lives are worlds apart.