Kou Yamori is an average middle school student who struggles with grasping the complex concept of love. Because he sees little sense in surrendering to the norm, he soon stops going to school. Plagued with insomnia due to his idleness, Kou begins roaming the lonesome streets at night. One night, Kou encounters a bizarre girl named Nazuna Nanakusa who believes that people stay awake during the night because they are dissatisfied with how they spent their day and cannot rest until they release their inhibitions. Nazuna offers to help Kou with his sleep issues and invites him over to her place, where she convinces him to share a futon with her. Feeling uncomfortable, Kou only pretends to doze off—which is when Nazuna suddenly bites his neck, revealing herself to be a vampire! While Kou thinks the bite will turn him into a vampire, the specifics of transforming are not that simple. In order to change, he must be bitten by someone he truly loves. Ready to let go of his dreary mortal life, Kou decides on a new goal: he will fall in love with Nazuna and become a vampire himself.

Due to a sudden accident, twins Haruka and Sora Kasugano have lost both of their parents. Starting their lives anew, they return to their childhood home—living once again in the rural, quaint town like they did four years ago. However, revisiting such a nostalgic place also means recalling all the memories the two of them made together, be it those that gave them blissful joy or those that made them suffer painful sorrow. Meeting both old acquaintances and new companions alike, the story of Haruka and Sora only gets more convoluted as their lives are slowly influenced by different acts of love, friendship, envy—and perhaps even lust.

Due to his mother and sister, who both love professional wrestling, Kinjirou Sakamachi developed a resilient body that could take hard punches, aggressive kicks, and even deadly vehicle bumps, in order to survive their various grappling positions and locks. However, he also developed gynophobia, an abnormal fear of women. With just one touch from a girl, his nose bleeds uncontrollably, he sweats excessively, and in rare cases, faints abruptly. His life changes for the worse because of a fated meeting in the restroom. While trying to escape from a girl, he discovers that the most popular student in their school, Subaru Konoe—the butler of the headmaster’s daughter, Kanade Suzutsuki—is actually female! Surprised, Subaru violently assaults Kinjirou, dealing significant damage and knocking him unconscious. When he comes to, he meets Kanade. In exchange for his silence, she promises to help cure his phobia.

While exploring Wiz's magic shop with his party, Kazuma Satou finds a magical wish-granting choker and decides to try it on. Only then does Wiz tell him that the choker strangles its wearer to death in four days unless their desires are fulfilled. This wouldn't be a problem if Kazuma knew what his wish was. Fearing for Kazuma's life, Aqua, Megumin, and Lalatina Ford Darkness Dustiness all agree to do his bidding in order to satisfy his desires and hopefully grant his wish, no matter what he asks for.