Having slept through all four of her alarms, the energetic Narumi Momose finds herself running late for her first day of work at a new office. As she races to catch her train, she makes a promise to herself that none of her coworkers will find out about her dark secret: that she is an otaku and a fujoshi. Her plan goes instantly awry, though, when she runs into Hirotaka Nifuji, an old friend from middle school. Although she tries to keep her secret by inviting him out for drinks after work, her cover is blown when he casually asks her whether or not she will be attending the upcoming Summer Comiket. Luckily for her, the only witnesses—Hanako Koyanagi and Tarou Kabakura—are otaku as well. Later that night, the pair go out for drinks so that they can catch up after all the years apart. After Narumi complains about her previous boyfriend breaking up with her because he refused to date a fujoshi, Hirotaka suggests that she try dating a fellow otaku, specifically himself. He makes a solemn promise to always be there for her, to support her, and to help her farm for rare drops in Monster Hunter. Blown away by the proposal, Narumi agrees immediately. Thus the two otaku start dating, and their adorably awkward romance begins.

When regular salaryman Yoshida wakes up one Sunday morning after a long night at the bar, the last thing he expects to see is that his tiny apartment has a new resident—an unfamiliar high school girl. The previous night, despite finally gathering the courage to confess to his boss and longtime crush, Airi Gotou, Yoshida was rejected. After drowning his sorrows at a bar with his good friend Hashimoto, Yoshida headed back to his home in a drunken stupor, only to run into Sayu Ogiwara, a runaway high schooler. She asked him to let her stay the night, and with his judgment clouded by alcohol, Yoshida complied. Now, with his head on straight but with no memory of last night's events, Yoshida has Sayu explain just how she ended up sleeping at his apartment. Having listened to her story, Yoshida finds himself unable to kick her out—especially after learning that she came all the way from Hokkaido! So, despite his reservations about sheltering an underage girl, Yoshida allows her to stay, and their life together begins.

After graduating from a top university with an impressive extracurricular record in the rugby club, Akira Tendou has nailed every step of the way to securing his dream job. On top of that, a beautiful and kind co-worker always brightens his day in the office! Life seems to be going very well for Akira until he slowly realizes that sleepless nights and brutal work are his new reality. Due to three years of mind-numbing labor in an exploitative company, Akira is unable to recognize the tired, unaccomplished person he has become. On track to losing all passion in life like several of his overworked colleagues, Akira finds his saving grace in the most unexpected way possible—the breakout of a zombie apocalypse. With the free time he finally has, Akira decides to complete a bucket list of a hundred things he wants to do before he eventually gets turned into a zombie. Although he is surrounded by the dead, Akira has never felt more alive!

Since childhood, Aoba Suzukaze has loved the Fairies Story game series, particularly the character designs. So when she graduates from high school, it is no surprise that she applies to work at Eagle Jump, the company responsible for making her favorite video game. On her first day, she is excited to learn that she will be working on a new installment to the series: Fairies Story 3—and even more so under Kou Yagami, the lead character designer. In their department are people who share the same passion for games. There is Yun Iijima, whose specialty is designing monsters; the shy Hifumi Takimoto, who prefers to communicate through instant messaging; Hajime Shinoda, an animation team member with an impressive figurine collection; Rin Tooyama, the orderly art director; Shizuku Hazuki, the game director who brings her cat to work; and Umiko Ahagon, the short-tempered head programmer. New Game! follows Aoba and the others on their adventure through the ups and downs of game making, from making the perfect character design to fixing all the errors that will inevitably accumulate in the process.